Fungal mycelia as the source of chitin and polysaccharides and their applications as skin substitutes

Ching Hua Su, Chi Shu Sun, Shan Wei Juan, Jun-Hung Hu, Wen Ting Ke, Ming Thau Sheu

研究成果: 雜誌貢獻文章同行評審

109 引文 斯高帕斯(Scopus)

摘要

A wovenable skin substitute (Sacchachitin) made from the residue of the fruiting body of Ganoderma tsugae was developed in this study. Chemical analysis revealed that the treated residue was a copolymer of β-1,3-glucan (ca 60%) and N-acetylglucosamine (ca 40%) with a filamental structure of mycelia form, as demonstrated by both optical and scanning electron microscopy. The pulp-like white residue was then woven into thin, porous sheets 7.0 cm in diameter and 0.1-0.2 mm in thickness by filtration and lyophilized for use as a skin substitute. The wound area produced by dissecting rat skin of full thickness was found to almost completely heal on the side covered with Sacchachitin, whereas the control side covered with cotton gauge was around 6.0 cm2 on the 28th day. Furthermore, the wound healing effects of the chitin sheet from crab shell (Beschitin®) and Sacchachitin were not found to be significantly different.
原文英語
頁(從 - 到)1169-1174
頁數6
期刊Biomaterials
18
發行號17
DOIs
出版狀態已發佈 - 9月 1997

ASJC Scopus subject areas

  • 生物技術
  • 生物工程
  • 生物醫學工程

指紋

深入研究「Fungal mycelia as the source of chitin and polysaccharides and their applications as skin substitutes」主題。共同形成了獨特的指紋。

引用此