Fungal infection of ventriculoperitoneal shunts in children

Chen Chia Chiou, Tai-Tong Wong, Hsi Hsun Lin, Betau Hwang, Ren Bin Tang, Keh Gong Wu, Bor Huey Lee

研究成果: 雜誌貢獻文章同行評審

60 引文 斯高帕斯(Scopus)

摘要

Infection is still the most common complicationof shunt procedures in children. However, fungal infection is still considered to be rare. We found that fungi accounted for 17% of shunt infections (8 of 48) in a retrospective study. Allof the patients were premature babies and had received a ventriculoperitoneal shunt because ofhydrocephalus. The clinical manifestations were subtle and insidious. The time of onset of infection ranged from 1 month to 1 year after the insertion of the shunt. Examination of the cerebrospinal fluid of infected patients showed mild pleocytosis with an elevated protein concentration. Candida species (including Candida albicans, Candida parapsilosis, and Candida tropicalis) or Torulopsis glabrata were isolated. In all but one case, shunts were removed and systemic therapy with amphotericin B was administered. Amphotericin B was given intrathecally to two patients, who did not respond to systemic therapy. Treatment with fluconazole failed for one patient. We suggest performing fungal cultures in cases of shunt infection, especially those involving premature infants. Extraventricular drainage, systemic therapy with amphotericin B, and insertion of a new shunt remain the principal components of the treatment regimen for fungal shunt infections in children.

原文英語
頁(從 - 到)1049-1053
頁數5
期刊Clinical Infectious Diseases
19
發行號6
DOIs
出版狀態已發佈 - 一月 1 1994
對外發佈

ASJC Scopus subject areas

  • 微生物學(醫學)
  • 傳染性疾病

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