摘要
DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research.
原文 | 英語 |
---|---|
頁(從 - 到) | 571-587 |
頁數 | 17 |
期刊 | Biology of the Cell |
卷 | 104 |
發行號 | 10 |
DOIs | |
出版狀態 | 已發佈 - 10月 1 2012 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 細胞生物學