Functions of DNA methyltransferase 3-like in germ cells and beyond

Hung Fu Liao, Kang Yu Tai, Wendy S.C. Chen, Luca C.W. Cheng, Hong Nerng Ho, Shau Ping Lin

研究成果: 雜誌貢獻回顧型文獻同行評審

21 引文 斯高帕斯(Scopus)

摘要

DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research.
原文英語
頁(從 - 到)571-587
頁數17
期刊Biology of the Cell
104
發行號10
DOIs
出版狀態已發佈 - 十月 1 2012
對外發佈

ASJC Scopus subject areas

  • 細胞生物學

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