Functional effects of let-7g expression in colon cancer metastasis

Che Mai Chang, Henry Sung Ching Wong, Chien Yu Huang, Wen Li Hsu, Zhi Feng Maio, Siou Jin Chiu, Yao Ting Tsai, Ben Kuen Chen, Yu Jui Yvonne Wan, Jaw Yuan Wang, Wei Chiao Chang

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

摘要

MicroRNA regulation is crucial for gene expression and cell functions. It has been linked to tumorigenesis, development and metastasis in colorectal cancer (CRC). Recently, the let-7 family has been identified as a tumor suppressor in different types of cancers. However, the function of the let-7 family in CRC metastasis has not been fully investigated. Here, we focused on analyzing the role of let-7g in CRC. The Cancer Genome Atlas (TCGA) genomic datasets of CRC and detailed data from a Taiwanese CRC cohort were applied to study the expression pattern of let-7g. In addition, in vitro as well as in vivo studies have been performed to uncover the effects of let-7g on CRC. We found that the expression of let-7g was significantly lower in CRC specimens. Our results further supported the inhibitory effects of let-7g on CRC cell migration, invasion and extracellular calcium influx through store-operated calcium channels. We report a critical role for let-7g in the pathogenesis of CRC and suggest let-7g as a potential therapeutic target for CRC treatment.

原文英語
文章編號489
期刊Cancers
11
發行號4
DOIs
出版狀態已發佈 - 四月 1 2019

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

指紋 深入研究「Functional effects of let-7g expression in colon cancer metastasis」主題。共同形成了獨特的指紋。

  • 引用此

    Chang, C. M., Wong, H. S. C., Huang, C. Y., Hsu, W. L., Maio, Z. F., Chiu, S. J., Tsai, Y. T., Chen, B. K., Wan, Y. J. Y., Wang, J. Y., & Chang, W. C. (2019). Functional effects of let-7g expression in colon cancer metastasis. Cancers, 11(4), [489]. https://doi.org/10.3390/cancers11040489