摘要

Background: Kawasaki disease (KD) is an acute systemic vasculitis syndrome with unknown pathogen. The immune system has been suggested to involve in the pathogenesis in KD. IP10 is a chemoattractant for initiating T-cell activation. The aim of this study was to investigate the association between genetic polymorphisms of IP10 and KD. Methods: A total of 354 KD patients and 1,709 control subjects (709 subjects in cohort 1 and 1,000 subjects in cohort 2) were enrolled in this study. Four tagging single nucleotide polymorphisms (rs3921, rs4256246, rs4508917, and rs4386624) were chosen for genotyping. Results: Our results indicated that CC genotype of rs3921 and GG genotype of rs4386624 had higher frequency in KD patients compared to control. In addition, higher plasma IP10 level was observed in CC genotype of rs3921 than CG genotype and GG genotype. C/G haplotype carriers of rs3921/rs4386624 had 5.48-fold risk for KD compared to G/C haplotype carriers. Two-locus analysis further showed the combinatorial effects of rs3921 and rs4386624 in KD susceptibility. Conclusions: This study indicated the close correlation between IP10 and the risk of Kawasaki disease.
原文英語
頁(從 - 到)363-370
頁數8
期刊Pediatric Allergy and Immunology
32
發行號2
DOIs
出版狀態已發佈 - 二月 2021

ASJC Scopus subject areas

  • 兒科、圍產兒和兒童健康
  • 免疫學和過敏
  • 免疫學

指紋

深入研究「Functional correlations between CXCL10/IP10 gene polymorphisms and risk of Kawasaki disease」主題。共同形成了獨特的指紋。

引用此