Functional connectivity of the corpus callosum in epilepsy patients with secondarily generalized seizures

Syu Jyun Peng, Yue Loong Hsin

研究成果: 雜誌貢獻文章同行評審

4 引文 斯高帕斯(Scopus)

摘要

The corpus callosum (CC) plays an important role in generalization of seizure activity. We used resting-state function magnetic resonance imaging (rs-fMRI) to investigate the regional and interregional functional connectivity of CC in patients with magnetic resonance imaging (MRI)-negative and secondarily generalized seizures. We measured the multi-regional coherences of blood oxygen level-dependent (BOLD) signals via rs-fMRI, cortical thickness via high-resolution T1-weighted MRI, and white matter (WM) integrity via diffusion-tensor imaging in 16 epilepsy patients as well as in 16 age- and gender-matched healthy subjects. All patients had non-lesional MRI, medically well-con-trolled focal epilepsy and history of secondarily generalized convulsions. Individuals with epilepsy had significant differences in regional and interregional hypersynchronization of BOLD signals intrahemispherically and interhemispherically, but no difference in cortical thickness and WM integrity. The only area with increased regional hypersynchrony in WM was over the anterior CC, which also exhibited lower activation of neighboring resting-state networks. The present study revealed abnormal local and distant synchronization of spontaneous neural activities in epileptic patients with secondarily generalized seizures.
原文英語
文章編號446
期刊Frontiers in Neurology
8
發行號AUG
DOIs
出版狀態已發佈 - 八月 30 2017
對外發佈

ASJC Scopus subject areas

  • 神經內科
  • 神經病學(臨床)

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