From smoking to cancers: Novel targets to neuronal nicotinic acetylcholine receptors

Chia-Hwa Lee, Chih-Hsiung Wu, Yuan-Soon Ho

研究成果: 雜誌貢獻回顧型文獻

13 引文 斯高帕斯(Scopus)

摘要

Cigarette smoking bears a strong etiological association with many neovascularization-related diseases, including cancer, cardiovascular disease, and age-related macular degeneration. Cigarette smoke is a complex mixture of many compounds, including nicotine, which is the major active and addictive component of tobacco. Nicotine and its specific metabolized carcinogens directly bind to nicotinic acetylcholine receptors (nAChRs) on cell membranes and trigger the nAChR signal cascade. The nAChRs were originally thought to be ligand-gated ion channels that modulate physiological processes ranging from neurotransmission to cancer signaling. For several decades, the nAChRs served as a prototypic molecule for neurotransmitter receptors; however, they are now important therapeutic targets for various diseases, including Alzheimer's and Parkinson's diseases, schizophrenia, and even cancer. This paper describes recent advances in our understanding of the assembly, activity, and biological functions of nicotinic receptors, as well as developments in the therapeutic application of nicotinic receptor ligands.
原文英語
文章編號693424
期刊Journal of Oncology
DOIs
出版狀態已發佈 - 2011

ASJC Scopus subject areas

  • Oncology

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