Frequency of vascular inflammation and impact on healing of 2nd generation drug eluting stents in porcine coronary arteries

Jong Shiuan Yeh, Seung Jin Oh

研究成果: 雜誌貢獻文章

摘要

Background: We aimed to describe the frequency of vascular inflammatory reactions in 2nd generation drug eluting stent as compared to 1 st generation technologies and analyze the impact on inflammation and neointimal proliferation in the porcine coronary model. Methods: A total of 26 stents (7 multi-link VISION, 6 CYPHER, 6 TAXUS and 7 XIENCE V) were deployed in coronary arteries of 10 domestic swine and followed up at 28 days. At termination, each stent was harvested and processed for histo-morphometric analysis. Results: A total of 202 histological segments were included. The mean neointimal thickness was significantly reduced in the Drug eluting stent group compared to the bare metal stent group. As a group, drug eluting stent displayed higher injury scores (0.99±0.79 versus 0.67±0.44, p50% (RR: 6.11, 95% CI: 2.97 to 12.59, p=0.001), Within the drug eluting stent group, the 2nd generation stents demonstrated lower neointimal area (XIENCE V: 1.64 ± 0.90 mm2) compared to the 1 st generation stents (TAXUS: 2.36 ± 1.56 mm2, p=0.005), (CYPHER 2.78 ± 1.82 mm2, p=0.001). The XIENCE V stents had lower inflammatory scores and lower frequency of para-strut granuloma in comparison to TAXUS and CYPHER stents. Conclusions: Second generation drug eluting stent displayed lower incidence of vascular inflammatory reaction compared to 1st generation drug eluting stent. This biological phenomenon appears to influence the patterns of neointimal formation and vascular healing.

原文英語
頁(從 - 到)3083-3100
頁數18
期刊Experimental and Clinical Cardiology
20
發行號8
出版狀態已發佈 - 2014

指紋

Drug-Eluting Stents
Stents
Blood Vessels
Coronary Vessels
Swine
Inflammation
Biological Phenomena
Granuloma
Metals
Technology
Incidence
Wounds and Injuries

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Physiology

引用此文

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title = "Frequency of vascular inflammation and impact on healing of 2nd generation drug eluting stents in porcine coronary arteries",
abstract = "Background: We aimed to describe the frequency of vascular inflammatory reactions in 2nd generation drug eluting stent as compared to 1 st generation technologies and analyze the impact on inflammation and neointimal proliferation in the porcine coronary model. Methods: A total of 26 stents (7 multi-link VISION, 6 CYPHER, 6 TAXUS and 7 XIENCE V) were deployed in coronary arteries of 10 domestic swine and followed up at 28 days. At termination, each stent was harvested and processed for histo-morphometric analysis. Results: A total of 202 histological segments were included. The mean neointimal thickness was significantly reduced in the Drug eluting stent group compared to the bare metal stent group. As a group, drug eluting stent displayed higher injury scores (0.99±0.79 versus 0.67±0.44, p50{\%} (RR: 6.11, 95{\%} CI: 2.97 to 12.59, p=0.001), Within the drug eluting stent group, the 2nd generation stents demonstrated lower neointimal area (XIENCE V: 1.64 ± 0.90 mm2) compared to the 1 st generation stents (TAXUS: 2.36 ± 1.56 mm2, p=0.005), (CYPHER 2.78 ± 1.82 mm2, p=0.001). The XIENCE V stents had lower inflammatory scores and lower frequency of para-strut granuloma in comparison to TAXUS and CYPHER stents. Conclusions: Second generation drug eluting stent displayed lower incidence of vascular inflammatory reaction compared to 1st generation drug eluting stent. This biological phenomenon appears to influence the patterns of neointimal formation and vascular healing.",
keywords = "Drug eluting stent, Porcine coronary artery, Vascular inflammation reaction",
author = "Yeh, {Jong Shiuan} and Oh, {Seung Jin}",
year = "2014",
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T1 - Frequency of vascular inflammation and impact on healing of 2nd generation drug eluting stents in porcine coronary arteries

AU - Yeh, Jong Shiuan

AU - Oh, Seung Jin

PY - 2014

Y1 - 2014

N2 - Background: We aimed to describe the frequency of vascular inflammatory reactions in 2nd generation drug eluting stent as compared to 1 st generation technologies and analyze the impact on inflammation and neointimal proliferation in the porcine coronary model. Methods: A total of 26 stents (7 multi-link VISION, 6 CYPHER, 6 TAXUS and 7 XIENCE V) were deployed in coronary arteries of 10 domestic swine and followed up at 28 days. At termination, each stent was harvested and processed for histo-morphometric analysis. Results: A total of 202 histological segments were included. The mean neointimal thickness was significantly reduced in the Drug eluting stent group compared to the bare metal stent group. As a group, drug eluting stent displayed higher injury scores (0.99±0.79 versus 0.67±0.44, p50% (RR: 6.11, 95% CI: 2.97 to 12.59, p=0.001), Within the drug eluting stent group, the 2nd generation stents demonstrated lower neointimal area (XIENCE V: 1.64 ± 0.90 mm2) compared to the 1 st generation stents (TAXUS: 2.36 ± 1.56 mm2, p=0.005), (CYPHER 2.78 ± 1.82 mm2, p=0.001). The XIENCE V stents had lower inflammatory scores and lower frequency of para-strut granuloma in comparison to TAXUS and CYPHER stents. Conclusions: Second generation drug eluting stent displayed lower incidence of vascular inflammatory reaction compared to 1st generation drug eluting stent. This biological phenomenon appears to influence the patterns of neointimal formation and vascular healing.

AB - Background: We aimed to describe the frequency of vascular inflammatory reactions in 2nd generation drug eluting stent as compared to 1 st generation technologies and analyze the impact on inflammation and neointimal proliferation in the porcine coronary model. Methods: A total of 26 stents (7 multi-link VISION, 6 CYPHER, 6 TAXUS and 7 XIENCE V) were deployed in coronary arteries of 10 domestic swine and followed up at 28 days. At termination, each stent was harvested and processed for histo-morphometric analysis. Results: A total of 202 histological segments were included. The mean neointimal thickness was significantly reduced in the Drug eluting stent group compared to the bare metal stent group. As a group, drug eluting stent displayed higher injury scores (0.99±0.79 versus 0.67±0.44, p50% (RR: 6.11, 95% CI: 2.97 to 12.59, p=0.001), Within the drug eluting stent group, the 2nd generation stents demonstrated lower neointimal area (XIENCE V: 1.64 ± 0.90 mm2) compared to the 1 st generation stents (TAXUS: 2.36 ± 1.56 mm2, p=0.005), (CYPHER 2.78 ± 1.82 mm2, p=0.001). The XIENCE V stents had lower inflammatory scores and lower frequency of para-strut granuloma in comparison to TAXUS and CYPHER stents. Conclusions: Second generation drug eluting stent displayed lower incidence of vascular inflammatory reaction compared to 1st generation drug eluting stent. This biological phenomenon appears to influence the patterns of neointimal formation and vascular healing.

KW - Drug eluting stent

KW - Porcine coronary artery

KW - Vascular inflammation reaction

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