Frequency and risk factors for barrett's esophagus in taiwanese patients: A prospective study in a tertiary referral center

Chia Jung Kuo, Cheng Hui Lin, Nai Jen Liu, Ren Chin Wu, Jui-Hsiang Tang, Chi Liang Cheng

研究成果: 雜誌貢獻文章

31 引文 (Scopus)

摘要

Background There is a paucity of epidemiologic data concerning Barrett's esophagus (BE) in Taiwan. Aim This study aimed to investigate the frequency of and risk factors for BE in self-referred Taiwanese patients undergoing diagnostic endoscopy. Methods A total of 736 consecutive patients undergoing upper endoscopy for a variety of gastro-intestinal symptoms from February to October 2007 were evaluated. A standard questionnaire was used to record the clinical characteristics and patient symptoms. Gastro-esophageal reflux disease (GERD) was diagnosed using the Montreal definition, while the Los Angeles Classification and Prague Circumferential and Maximal Criteria were used to assess erosive esophagitis and BE, respectively. Four-quadrant biopsies were taken from endoscopically suspected esophageal metaplastic mucosa every 2 cm for histologic evaluation. Eight variables were tested using a logistic regression model to identify risk factors for BE in GERD patients. Results GERD was diagnosed in 344 patients, wit typical esophageal symptoms noted in 255, reflux chest pain syndrome in 107, and extra-esophageal syndrome in 51, while 27 were asymptomatic. The mean age of the GERD patients was 49.8 years and 55.5% of them were male. Thirty-six percent (123 of 344) demonstrated erosive esophagitis and 95% were classified as having Los Angeles grade A or B disease. BE was diagnosed in 13 patients (3.8% of GERD patients), three of whom had dysplastic mucosa. In the final analysis model, hiatal hernia (odds ratio [OR] = 4.7, 95% confidence interval [CI] = 1.3-17.7, P = 0.02) and GERD duration >5 years (OR = 4.2, 95%CI = 1.2-4.8,P = 0.03) were independent risk factors for the development of BE. Conclusion There is a 3.8% frequency of BE in Taiwanese GERD patients. Hiatal hernia and prolonged GERD duration are significant risk factors.

原文英語
頁(從 - 到)1337-1343
頁數7
期刊Digestive Diseases and Sciences
55
發行號5
DOIs
出版狀態已發佈 - 五月 1 2010
對外發佈Yes

指紋

Esophageal Diseases
Barrett Esophagus
Tertiary Care Centers
Gastroesophageal Reflux
Prospective Studies
Hiatal Hernia
Los Angeles
Esophagitis
Endoscopy
Logistic Models
Odds Ratio
Confidence Intervals
Wit and Humor
Chest Pain
Taiwan
Mucous Membrane
Biopsy

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

引用此文

Frequency and risk factors for barrett's esophagus in taiwanese patients : A prospective study in a tertiary referral center. / Kuo, Chia Jung; Lin, Cheng Hui; Liu, Nai Jen; Wu, Ren Chin; Tang, Jui-Hsiang; Cheng, Chi Liang.

於: Digestive Diseases and Sciences, 卷 55, 編號 5, 01.05.2010, p. 1337-1343.

研究成果: 雜誌貢獻文章

Kuo, Chia Jung ; Lin, Cheng Hui ; Liu, Nai Jen ; Wu, Ren Chin ; Tang, Jui-Hsiang ; Cheng, Chi Liang. / Frequency and risk factors for barrett's esophagus in taiwanese patients : A prospective study in a tertiary referral center. 於: Digestive Diseases and Sciences. 2010 ; 卷 55, 編號 5. 頁 1337-1343.
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abstract = "Background There is a paucity of epidemiologic data concerning Barrett's esophagus (BE) in Taiwan. Aim This study aimed to investigate the frequency of and risk factors for BE in self-referred Taiwanese patients undergoing diagnostic endoscopy. Methods A total of 736 consecutive patients undergoing upper endoscopy for a variety of gastro-intestinal symptoms from February to October 2007 were evaluated. A standard questionnaire was used to record the clinical characteristics and patient symptoms. Gastro-esophageal reflux disease (GERD) was diagnosed using the Montreal definition, while the Los Angeles Classification and Prague Circumferential and Maximal Criteria were used to assess erosive esophagitis and BE, respectively. Four-quadrant biopsies were taken from endoscopically suspected esophageal metaplastic mucosa every 2 cm for histologic evaluation. Eight variables were tested using a logistic regression model to identify risk factors for BE in GERD patients. Results GERD was diagnosed in 344 patients, wit typical esophageal symptoms noted in 255, reflux chest pain syndrome in 107, and extra-esophageal syndrome in 51, while 27 were asymptomatic. The mean age of the GERD patients was 49.8 years and 55.5{\%} of them were male. Thirty-six percent (123 of 344) demonstrated erosive esophagitis and 95{\%} were classified as having Los Angeles grade A or B disease. BE was diagnosed in 13 patients (3.8{\%} of GERD patients), three of whom had dysplastic mucosa. In the final analysis model, hiatal hernia (odds ratio [OR] = 4.7, 95{\%} confidence interval [CI] = 1.3-17.7, P = 0.02) and GERD duration >5 years (OR = 4.2, 95{\%}CI = 1.2-4.8,P = 0.03) were independent risk factors for the development of BE. Conclusion There is a 3.8{\%} frequency of BE in Taiwanese GERD patients. Hiatal hernia and prolonged GERD duration are significant risk factors.",
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author = "Kuo, {Chia Jung} and Lin, {Cheng Hui} and Liu, {Nai Jen} and Wu, {Ren Chin} and Jui-Hsiang Tang and Cheng, {Chi Liang}",
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T1 - Frequency and risk factors for barrett's esophagus in taiwanese patients

T2 - A prospective study in a tertiary referral center

AU - Kuo, Chia Jung

AU - Lin, Cheng Hui

AU - Liu, Nai Jen

AU - Wu, Ren Chin

AU - Tang, Jui-Hsiang

AU - Cheng, Chi Liang

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Background There is a paucity of epidemiologic data concerning Barrett's esophagus (BE) in Taiwan. Aim This study aimed to investigate the frequency of and risk factors for BE in self-referred Taiwanese patients undergoing diagnostic endoscopy. Methods A total of 736 consecutive patients undergoing upper endoscopy for a variety of gastro-intestinal symptoms from February to October 2007 were evaluated. A standard questionnaire was used to record the clinical characteristics and patient symptoms. Gastro-esophageal reflux disease (GERD) was diagnosed using the Montreal definition, while the Los Angeles Classification and Prague Circumferential and Maximal Criteria were used to assess erosive esophagitis and BE, respectively. Four-quadrant biopsies were taken from endoscopically suspected esophageal metaplastic mucosa every 2 cm for histologic evaluation. Eight variables were tested using a logistic regression model to identify risk factors for BE in GERD patients. Results GERD was diagnosed in 344 patients, wit typical esophageal symptoms noted in 255, reflux chest pain syndrome in 107, and extra-esophageal syndrome in 51, while 27 were asymptomatic. The mean age of the GERD patients was 49.8 years and 55.5% of them were male. Thirty-six percent (123 of 344) demonstrated erosive esophagitis and 95% were classified as having Los Angeles grade A or B disease. BE was diagnosed in 13 patients (3.8% of GERD patients), three of whom had dysplastic mucosa. In the final analysis model, hiatal hernia (odds ratio [OR] = 4.7, 95% confidence interval [CI] = 1.3-17.7, P = 0.02) and GERD duration >5 years (OR = 4.2, 95%CI = 1.2-4.8,P = 0.03) were independent risk factors for the development of BE. Conclusion There is a 3.8% frequency of BE in Taiwanese GERD patients. Hiatal hernia and prolonged GERD duration are significant risk factors.

AB - Background There is a paucity of epidemiologic data concerning Barrett's esophagus (BE) in Taiwan. Aim This study aimed to investigate the frequency of and risk factors for BE in self-referred Taiwanese patients undergoing diagnostic endoscopy. Methods A total of 736 consecutive patients undergoing upper endoscopy for a variety of gastro-intestinal symptoms from February to October 2007 were evaluated. A standard questionnaire was used to record the clinical characteristics and patient symptoms. Gastro-esophageal reflux disease (GERD) was diagnosed using the Montreal definition, while the Los Angeles Classification and Prague Circumferential and Maximal Criteria were used to assess erosive esophagitis and BE, respectively. Four-quadrant biopsies were taken from endoscopically suspected esophageal metaplastic mucosa every 2 cm for histologic evaluation. Eight variables were tested using a logistic regression model to identify risk factors for BE in GERD patients. Results GERD was diagnosed in 344 patients, wit typical esophageal symptoms noted in 255, reflux chest pain syndrome in 107, and extra-esophageal syndrome in 51, while 27 were asymptomatic. The mean age of the GERD patients was 49.8 years and 55.5% of them were male. Thirty-six percent (123 of 344) demonstrated erosive esophagitis and 95% were classified as having Los Angeles grade A or B disease. BE was diagnosed in 13 patients (3.8% of GERD patients), three of whom had dysplastic mucosa. In the final analysis model, hiatal hernia (odds ratio [OR] = 4.7, 95% confidence interval [CI] = 1.3-17.7, P = 0.02) and GERD duration >5 years (OR = 4.2, 95%CI = 1.2-4.8,P = 0.03) were independent risk factors for the development of BE. Conclusion There is a 3.8% frequency of BE in Taiwanese GERD patients. Hiatal hernia and prolonged GERD duration are significant risk factors.

KW - Barrett's esophagus

KW - Endoscopy

KW - Gastro-esophageal reflux disease

KW - Hiatal hernia

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