Free/total prostate specific antigen ratio for prostate cancer detection: A prospective blind study

Chi Rei Yang, Chung Knang Su, Kun Yuan Chiu, Hao Chung Ho, Yen Chuan Ou, Cheng Li Cheng, Huei Lee

研究成果: 雜誌貢獻文章同行評審

4 引文 斯高帕斯(Scopus)

摘要

Background: We conducted this prospective study to evaluate the ability of the percentage of free PSA (% f/t PSA) to improve the specificity of prostate cancer (PC) detection. Materials and Methods: Seven hundred and eighty-five patients with serum PSA levels between 4 and 25 ng/ml underwent sextant biopsies of the prostate. The % f/t PSA was analyzed for the sensitivity, specificity and positive predictive values. Results: The mean % f/t PSA of the 169 patients with PC was 18.0 ± 7.7 and was significantly (p <0.0001) lower than that of the 616 patients who had histologically benign biopsy specimens, with a mean % f/t PSA of 26.6 ± 9.7. Using 30% f/t PSA as the cut-off eliminated 34.4% of the negative biopsies while still detecting 93.4% of the carcinomas. Conclusion: The optimal cut-off value of 30% f/t PSA may be applied as reference using the Cis bio international assay for PC detection.
原文英語
頁(從 - 到)2439-2443
頁數5
期刊Anticancer Research
25
發行號3 C
出版狀態已發佈 - 五月 2005
對外發佈

ASJC Scopus subject areas

  • 癌症研究
  • 腫瘤科

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