Frame-based stereotactic deep brain stimulation for parkinson's disease

12 months outcomes for patients in cross hair versus non-cross hair application groups

Tung Han Tsai, Da Tong Ju, Yi Lin Yu, Chi Tun Tang, Yu Ching Chou, Yung Hsiao Chiang, Shinn Zong Lin, Yuan Hao Chen

研究成果: 雜誌貢獻文章

摘要

Background: Because deep brain stimulation (DBS) implantations and other stereotactic and functional surgical procedures require accurate, precise, and safe targeting of the brain structure, the technical aids for preoperative planning, intervention, and postoperative follow-up have become increasingly important. In this paper, we compare the outcomes of advanced Parkinson's disease (PD) patients at our center who received frame-based DBS surgery involving the use of a cross hair with those for patients who received the surgery without the application of the cross hair. A preliminary outcomes analysis is also provided. Methods and Techniques: Seventeen patients (10 male and 7 female; mean age: 64.8 ± 9.0 years) with advanced PD underwent frame-based DBS surgery, 8 with noncross hair and 9 with cross hair frame-based stereotaxy. After identifying the coordinates of the subthalamic nuclei, the DBS electrodes were implanted with or without crosshair application and connected to an implanted programmable generator in all patients. Programming started 1 month after the operation, and the patients were followed-upon regularly for at least 6 months. Results: After 12 months of follow-up, the patients who received DBS surgery showed improvements in clinical outcome, especially those in the frame-based cross hair group, which resulted in a significantly higher degree of improvement in both the "On" and "Off" states of the postoperative state (cross hair Unified PD Rating Scale [UPDRS] in the "Off" state: Preoperative: 82.3 ± 15.4 vs. postoperative: 37.9 ± 9.4; P <0.001; UPDRS in the "On" state: Preoperative: 47.8 ± 13.6 vs. postoperative "On" state: 28.6 ± 6.0; P <0.01, paired t-test). However, improvements were shown only in the "On" state of the noncross hair group (noncross hair group UPDRS in the "Off" state: Preoperative: 71.7 ± 16.6 vs. postoperative 48.9 ± 24.4; P <0.05; "On" state: Preoperative: 55.2 ± 19.1 vs. postoperative: 42.6 ± 27.8; P > 0.05, paired t-test). Conclusion: Targeting accuracy can be increased by detailed preoperative planning and good facilitating equipment. Crosshair application with a frame-based system provides higher accuracy in the postoperative lead position survey and target deviation measurements compared with the preoperative planning image. Furthermore, the outcomes of the DBS group with cross hair application were better than those of the noncross hair application group.

原文英語
頁(從 - 到)166-174
頁數9
期刊Journal of Medical Sciences (Taiwan)
34
發行號4
DOIs
出版狀態已發佈 - 2014

指紋

Deep Brain Stimulation
Hair
Parkinson Disease
Subthalamic Nucleus
Implanted Electrodes
Parkinson Disease 12
Equipment and Supplies
Brain

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Frame-based stereotactic deep brain stimulation for parkinson's disease : 12 months outcomes for patients in cross hair versus non-cross hair application groups. / Tsai, Tung Han; Ju, Da Tong; Yu, Yi Lin; Tang, Chi Tun; Chou, Yu Ching; Chiang, Yung Hsiao; Lin, Shinn Zong; Chen, Yuan Hao.

於: Journal of Medical Sciences (Taiwan), 卷 34, 編號 4, 2014, p. 166-174.

研究成果: 雜誌貢獻文章

Tsai, Tung Han ; Ju, Da Tong ; Yu, Yi Lin ; Tang, Chi Tun ; Chou, Yu Ching ; Chiang, Yung Hsiao ; Lin, Shinn Zong ; Chen, Yuan Hao. / Frame-based stereotactic deep brain stimulation for parkinson's disease : 12 months outcomes for patients in cross hair versus non-cross hair application groups. 於: Journal of Medical Sciences (Taiwan). 2014 ; 卷 34, 編號 4. 頁 166-174.
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abstract = "Background: Because deep brain stimulation (DBS) implantations and other stereotactic and functional surgical procedures require accurate, precise, and safe targeting of the brain structure, the technical aids for preoperative planning, intervention, and postoperative follow-up have become increasingly important. In this paper, we compare the outcomes of advanced Parkinson's disease (PD) patients at our center who received frame-based DBS surgery involving the use of a cross hair with those for patients who received the surgery without the application of the cross hair. A preliminary outcomes analysis is also provided. Methods and Techniques: Seventeen patients (10 male and 7 female; mean age: 64.8 ± 9.0 years) with advanced PD underwent frame-based DBS surgery, 8 with noncross hair and 9 with cross hair frame-based stereotaxy. After identifying the coordinates of the subthalamic nuclei, the DBS electrodes were implanted with or without crosshair application and connected to an implanted programmable generator in all patients. Programming started 1 month after the operation, and the patients were followed-upon regularly for at least 6 months. Results: After 12 months of follow-up, the patients who received DBS surgery showed improvements in clinical outcome, especially those in the frame-based cross hair group, which resulted in a significantly higher degree of improvement in both the {"}On{"} and {"}Off{"} states of the postoperative state (cross hair Unified PD Rating Scale [UPDRS] in the {"}Off{"} state: Preoperative: 82.3 ± 15.4 vs. postoperative: 37.9 ± 9.4; P <0.001; UPDRS in the {"}On{"} state: Preoperative: 47.8 ± 13.6 vs. postoperative {"}On{"} state: 28.6 ± 6.0; P <0.01, paired t-test). However, improvements were shown only in the {"}On{"} state of the noncross hair group (noncross hair group UPDRS in the {"}Off{"} state: Preoperative: 71.7 ± 16.6 vs. postoperative 48.9 ± 24.4; P <0.05; {"}On{"} state: Preoperative: 55.2 ± 19.1 vs. postoperative: 42.6 ± 27.8; P > 0.05, paired t-test). Conclusion: Targeting accuracy can be increased by detailed preoperative planning and good facilitating equipment. Crosshair application with a frame-based system provides higher accuracy in the postoperative lead position survey and target deviation measurements compared with the preoperative planning image. Furthermore, the outcomes of the DBS group with cross hair application were better than those of the noncross hair application group.",
keywords = "Advanced parkinson's disease, Deep brain stimulation, Frame-based stereotactic",
author = "Tsai, {Tung Han} and Ju, {Da Tong} and Yu, {Yi Lin} and Tang, {Chi Tun} and Chou, {Yu Ching} and Chiang, {Yung Hsiao} and Lin, {Shinn Zong} and Chen, {Yuan Hao}",
year = "2014",
doi = "10.4103/1011-4564.139189",
language = "English",
volume = "34",
pages = "166--174",
journal = "Journal of Medical Sciences",
issn = "1011-4564",
publisher = "國防醫學院",
number = "4",

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T1 - Frame-based stereotactic deep brain stimulation for parkinson's disease

T2 - 12 months outcomes for patients in cross hair versus non-cross hair application groups

AU - Tsai, Tung Han

AU - Ju, Da Tong

AU - Yu, Yi Lin

AU - Tang, Chi Tun

AU - Chou, Yu Ching

AU - Chiang, Yung Hsiao

AU - Lin, Shinn Zong

AU - Chen, Yuan Hao

PY - 2014

Y1 - 2014

N2 - Background: Because deep brain stimulation (DBS) implantations and other stereotactic and functional surgical procedures require accurate, precise, and safe targeting of the brain structure, the technical aids for preoperative planning, intervention, and postoperative follow-up have become increasingly important. In this paper, we compare the outcomes of advanced Parkinson's disease (PD) patients at our center who received frame-based DBS surgery involving the use of a cross hair with those for patients who received the surgery without the application of the cross hair. A preliminary outcomes analysis is also provided. Methods and Techniques: Seventeen patients (10 male and 7 female; mean age: 64.8 ± 9.0 years) with advanced PD underwent frame-based DBS surgery, 8 with noncross hair and 9 with cross hair frame-based stereotaxy. After identifying the coordinates of the subthalamic nuclei, the DBS electrodes were implanted with or without crosshair application and connected to an implanted programmable generator in all patients. Programming started 1 month after the operation, and the patients were followed-upon regularly for at least 6 months. Results: After 12 months of follow-up, the patients who received DBS surgery showed improvements in clinical outcome, especially those in the frame-based cross hair group, which resulted in a significantly higher degree of improvement in both the "On" and "Off" states of the postoperative state (cross hair Unified PD Rating Scale [UPDRS] in the "Off" state: Preoperative: 82.3 ± 15.4 vs. postoperative: 37.9 ± 9.4; P <0.001; UPDRS in the "On" state: Preoperative: 47.8 ± 13.6 vs. postoperative "On" state: 28.6 ± 6.0; P <0.01, paired t-test). However, improvements were shown only in the "On" state of the noncross hair group (noncross hair group UPDRS in the "Off" state: Preoperative: 71.7 ± 16.6 vs. postoperative 48.9 ± 24.4; P <0.05; "On" state: Preoperative: 55.2 ± 19.1 vs. postoperative: 42.6 ± 27.8; P > 0.05, paired t-test). Conclusion: Targeting accuracy can be increased by detailed preoperative planning and good facilitating equipment. Crosshair application with a frame-based system provides higher accuracy in the postoperative lead position survey and target deviation measurements compared with the preoperative planning image. Furthermore, the outcomes of the DBS group with cross hair application were better than those of the noncross hair application group.

AB - Background: Because deep brain stimulation (DBS) implantations and other stereotactic and functional surgical procedures require accurate, precise, and safe targeting of the brain structure, the technical aids for preoperative planning, intervention, and postoperative follow-up have become increasingly important. In this paper, we compare the outcomes of advanced Parkinson's disease (PD) patients at our center who received frame-based DBS surgery involving the use of a cross hair with those for patients who received the surgery without the application of the cross hair. A preliminary outcomes analysis is also provided. Methods and Techniques: Seventeen patients (10 male and 7 female; mean age: 64.8 ± 9.0 years) with advanced PD underwent frame-based DBS surgery, 8 with noncross hair and 9 with cross hair frame-based stereotaxy. After identifying the coordinates of the subthalamic nuclei, the DBS electrodes were implanted with or without crosshair application and connected to an implanted programmable generator in all patients. Programming started 1 month after the operation, and the patients were followed-upon regularly for at least 6 months. Results: After 12 months of follow-up, the patients who received DBS surgery showed improvements in clinical outcome, especially those in the frame-based cross hair group, which resulted in a significantly higher degree of improvement in both the "On" and "Off" states of the postoperative state (cross hair Unified PD Rating Scale [UPDRS] in the "Off" state: Preoperative: 82.3 ± 15.4 vs. postoperative: 37.9 ± 9.4; P <0.001; UPDRS in the "On" state: Preoperative: 47.8 ± 13.6 vs. postoperative "On" state: 28.6 ± 6.0; P <0.01, paired t-test). However, improvements were shown only in the "On" state of the noncross hair group (noncross hair group UPDRS in the "Off" state: Preoperative: 71.7 ± 16.6 vs. postoperative 48.9 ± 24.4; P <0.05; "On" state: Preoperative: 55.2 ± 19.1 vs. postoperative: 42.6 ± 27.8; P > 0.05, paired t-test). Conclusion: Targeting accuracy can be increased by detailed preoperative planning and good facilitating equipment. Crosshair application with a frame-based system provides higher accuracy in the postoperative lead position survey and target deviation measurements compared with the preoperative planning image. Furthermore, the outcomes of the DBS group with cross hair application were better than those of the noncross hair application group.

KW - Advanced parkinson's disease

KW - Deep brain stimulation

KW - Frame-based stereotactic

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