Fractional anisotropy in corpus callosum is associated with facilitation of motor representation during ipsilateral hand movements

Shin-Yi Chiou, Ray-Yau Wang, Richard Edward Roberts, Yu-Te Wu, Chia-Feng Lu, Kwong-Kum Liao, Yea-Ru Yang

研究成果: 雜誌貢獻文章

7 引文 (Scopus)

摘要

Background: Coactivation of primary motor cortex ipsilateral to a unilateral movement (M1ipsilateral) has been observed, and the magnitude of activation is influenced by the contracting muscles. It has been suggested that the microstructural integrity of the callosal motor fibers (CMFs) connecting M1 regions may reflect the observed response. However, the association between the structural connectivity of CMFs and functional changes in M1ipsilateral remains unclear. The purpose of this study was to investigate the relationship between functional changes within M1 ipsilateral during unilateral arm or leg movements and the microstructure of the CMFs connecting both homotopic representations (arm or leg). Methods: Transcranial magnetic stimulation was used to assess changes in motor evoked potentials (MEP) in an arm muscle during unilateral movements compared to rest in fifteen healthy adults. Functional magnetic resonance imaging was then used to identify regions of M1 associated with either arm or leg movements. Diffusion-weighted imaging data was acquired to generate CMFs for arm and leg areas using the areas of activation from the functional imaging as seed masks. Individual values of regional fractional anisotropy (FA) of arm and leg CMFs was then calculated by examining the overlap between CMFs and a standard atlas of corpus callosum. Results: The change in the MEP was significantly larger in the arm movement compared to the leg movement. Additionally, regression analysis revealed that FA in the arm CMFs was positively correlated with the change in MEP during arm movement, whereas a negative correlation was observed during the leg movement. However, there was no significant relationship between FA in the leg CMF and the change in MEP during the movements. Conclusions: These findings suggest that individual differences in interhemispheric structural connectivity may be used to explain a homologous muscle-dominant effect within M1ipsilateral hand representation during unilateral movement with topographical specificity. © 2014 Chiou et al.
原文英語
期刊PLoS One
9
發行號8
DOIs
出版狀態已發佈 - 2014
對外發佈Yes

指紋

Corpus Callosum
Anisotropy
legs
hands
Arm
Hand
Leg
evoked potentials
Motor Evoked Potentials
Fibers
Bioelectric potentials
muscles
Muscles
Muscle
image analysis
Transcranial Magnetic Stimulation
Atlases
magnetic resonance imaging
Motor Cortex
Chemical activation

引用此文

Fractional anisotropy in corpus callosum is associated with facilitation of motor representation during ipsilateral hand movements. / Chiou, Shin-Yi; Wang, Ray-Yau; Roberts, Richard Edward; Wu, Yu-Te; Lu, Chia-Feng; Liao, Kwong-Kum; Yang, Yea-Ru.

於: PLoS One, 卷 9, 編號 8, 2014.

研究成果: 雜誌貢獻文章

Chiou, Shin-Yi ; Wang, Ray-Yau ; Roberts, Richard Edward ; Wu, Yu-Te ; Lu, Chia-Feng ; Liao, Kwong-Kum ; Yang, Yea-Ru. / Fractional anisotropy in corpus callosum is associated with facilitation of motor representation during ipsilateral hand movements. 於: PLoS One. 2014 ; 卷 9, 編號 8.
@article{c3da7154c7dc405db12710b090c71de2,
title = "Fractional anisotropy in corpus callosum is associated with facilitation of motor representation during ipsilateral hand movements",
abstract = "Background: Coactivation of primary motor cortex ipsilateral to a unilateral movement (M1ipsilateral) has been observed, and the magnitude of activation is influenced by the contracting muscles. It has been suggested that the microstructural integrity of the callosal motor fibers (CMFs) connecting M1 regions may reflect the observed response. However, the association between the structural connectivity of CMFs and functional changes in M1ipsilateral remains unclear. The purpose of this study was to investigate the relationship between functional changes within M1 ipsilateral during unilateral arm or leg movements and the microstructure of the CMFs connecting both homotopic representations (arm or leg). Methods: Transcranial magnetic stimulation was used to assess changes in motor evoked potentials (MEP) in an arm muscle during unilateral movements compared to rest in fifteen healthy adults. Functional magnetic resonance imaging was then used to identify regions of M1 associated with either arm or leg movements. Diffusion-weighted imaging data was acquired to generate CMFs for arm and leg areas using the areas of activation from the functional imaging as seed masks. Individual values of regional fractional anisotropy (FA) of arm and leg CMFs was then calculated by examining the overlap between CMFs and a standard atlas of corpus callosum. Results: The change in the MEP was significantly larger in the arm movement compared to the leg movement. Additionally, regression analysis revealed that FA in the arm CMFs was positively correlated with the change in MEP during arm movement, whereas a negative correlation was observed during the leg movement. However, there was no significant relationship between FA in the leg CMF and the change in MEP during the movements. Conclusions: These findings suggest that individual differences in interhemispheric structural connectivity may be used to explain a homologous muscle-dominant effect within M1ipsilateral hand representation during unilateral movement with topographical specificity. {\circledC} 2014 Chiou et al.",
keywords = "adult, anisotropy, brain mapping, corpus callosum, diffusion weighted imaging, evoked muscle response, female, hand, hemispheric dominance, human, leg, male, motor cortex, muscle contraction, nuclear magnetic resonance imaging, physiology, psychomotor performance, regression analysis, transcranial magnetic stimulation, Adult, Anisotropy, Brain Mapping, Corpus Callosum, Diffusion Magnetic Resonance Imaging, Evoked Potentials, Motor, Female, Functional Laterality, Hand, Humans, Leg, Magnetic Resonance Imaging, Male, Motor Cortex, Muscle Contraction, Psychomotor Performance, Regression Analysis, Transcranial Magnetic Stimulation",
author = "Shin-Yi Chiou and Ray-Yau Wang and Roberts, {Richard Edward} and Yu-Te Wu and Chia-Feng Lu and Kwong-Kum Liao and Yea-Ru Yang",
note = "Export Date: 31 March 2016 CODEN: POLNC 參考文獻: Stippich, C., Blatow, M., Durst, A., Dreyhaupt, J., Sartor, K., Global activation of primary motor cortex during voluntary movements in man (2007) NeuroImage, 34 (3), pp. 1227-1237. , DOI 10.1016/j.neuroimage.2006.08.046, PII S1053811906008834; Chiou, S.Y., Wang, R.Y., Liao, K.K., Yang, Y.R., Homologous muscle contraction during unilateral movement does not show a dominant effect on leg representation of the ipsilateral primary motor cortex (2013) PLoS One, 8, pp. e72231; Chiou, S.Y., Wang, R.Y., Liao, K.K., Wu, Y.T., Lu, C.F., Co-activation of primary motor cortex ipsilateral to muscles contracting in a unilateral motor task (2013) Clin Neurophysiol, 124, pp. 1353-1363; Hess, C.W., Hunziker, T., Kupfer, A., Ludin, H.P., Thalidomide-induced peripheral neuropathy. A prospective clinical, neurophysiological and pharmacogenetic evaluation (1986) Journal of Neurology, 233 (2), pp. 83-89; Meyer, B.U., R{\"o}richt, S., Gr{\"a}fin Von Einsiedel, H., Kruggel, F., Weindl, A., Inhibitory and excitatory interhemispheric transfers between motor cortical areas in normal humans and patients with abnormalities of the corpus callosum (1995) Brain, 118, pp. 429-440; Stedman, A., Davey, N.J., Ellaway, P.H., Facilitation of human first dorsal interosseous muscle responses to transcranial magnetic stimulation during voluntary contraction of the contralateral homonymous muscle (1998) Muscle and Nerve, 21 (8), pp. 1033-1039. , DOI 10.1002/(SICI)1097-4598(199808)21:8<1033::AID; Tinazzi, M., Zanette, G., Modulation of ipsilateral motor cortex in man during unimanual finger movements of different complexities (1998) Neuroscience Letters, 244 (3), pp. 121-124. , DOI 10.1016/S0304-3940(98)00150-5; Muellbacher, W., Facchini, S., Boroojerdi, B., Hallett, M., Changes in motor cortex excitability during ipsilateral hand muscle activation in humans (2000) Clinical Neurophysiology, 111 (2), pp. 344-349. , DOI 10.1016/S1388-2457(99)00243-6, PII S1388245799002436; Hortobagyi, T., Taylor, J.L., Petersen, N.T., Russell, G., Gandevia, S.C., Changes in segmental and motor cortical output with contralateral muscle contractions and altered sensory inputs in humans (2003) Journal of Neurophysiology, 90 (4), pp. 2451-2459. , DOI 10.1152/jn.01001.2002; Chen, R., Interactions between inhibitory and excitatory circuits in the human motor cortex (2004) Exp Brain Res, 154, pp. 1-10; Harris-Love, M.L., Perez, M.A., Chen, R., Cohen, L.G., Interhemispheric inhibition in distal and proximal arm representations in the primary motor cortex (2007) Journal of Neurophysiology, 97 (3), pp. 2511-2515. , http://jn.physiology.org/cgi/reprint/97/3/2511, DOI 10.1152/jn.01331.2006; Perez, M.A., Cohen, L.G., Mechanisms underlying functional changes in the primary motor cortex ipsilateral to an active hand (2008) J Neurosci, 28, pp. 5631-5640; Hortob{\'a}gyi, T., Richardson, S.P., Lomarev, M., Shamim, E., Meunier, S., Interhemispheric plasticity in humans (2011) Med Sci Sports Exerc, 43, pp. 1188-1199; Stinear, C.M., Walker, K.S., Byblow, W.D., Symmetric facilitation between motor cortices during contraction of ipsilateral hand muscles (2001) Experimental Brain Research, 139 (1), pp. 101-105. , DOI 10.1007/s002210100758; Carson, R.G., Neural pathways mediating bilateral interactions between the upper limbs (2005) Brain Res Brain Res Rev, 49, pp. 641-662; Beaulieu, C., The basis of anisotropic water diffusion in the nervous system - A technical review (2002) NMR Biomed, 15, pp. 435-455; Moseley, M.E., Cohen, Y., Mintorovitch, J., Chileuitt, L., Shimizu, H., Kucharczyk, J., Wendland, M.F., Weinstein, P.R., Early detection of regional cerebral ischemia in cats: Comparison of diffusion- and T2-weighted MRI and spectroscopy (1990) Magnetic Resonance in Medicine, 14 (2), pp. 330-346. , DOI 10.1002/mrm.1910140218; Le Bihan, D., Looking into the functional architecture of the brain with diffusion MRI (2003) Nat Rev Neurosci, 4, pp. 469-480; Le, B.D., Mangin, J.-F., Poupon, C., Clark, C.A., Pappata, S., Molko, N., Chabriat, H., Diffusion tensor imaging: Concepts and applications (2001) Journal of Magnetic Resonance Imaging, 13 (4), pp. 534-546. , DOI 10.1002/jmri.1076; Pfefferbaum, A., Adalsteinsson, E., Sullivan, E.V., Replicability of diffusion tensor imaging measurements of fractional anisotropy and trace in brain (2003) Journal of Magnetic Resonance Imaging, 18 (4), pp. 427-433. , DOI 10.1002/jmri.10377; Madden, D.J., Whiting, W.L., Huettel, S.A., White, L.E., MacFall, J.R., Provenzale, J.M., Diffusion tensor imaging of adult age differences in cerebral white matter: Relation to response time (2004) NeuroImage, 21 (3), pp. 1174-1181. , DOI 10.1016/j.neuroimage.2003.11.004, PII S1053811903007249; Deutsch, G.K., Dougherty, R.F., Bammer, R., Siok, W.T., Gabrieli, J.D.E., Wandell, B., Children's reading performance is correlated with white matter structure measured by diffusion tensor imaging (2005) Cortex, 41 (3), pp. 354-363; Schulte, T., Sullivan, E.V., Muller-Oehring, E.M., Adalsteinsson, E., Pfefferbaum, A., Corpus callosal microstructural integrity influences interhemispheric processing: A diffusion tensor imaging study (2005) Cerebral Cortex, 15 (9), pp. 1384-1392. , DOI 10.1093/cercor/bhi020; Tuch, D.S., Salat, D.H., Wisco, J.J., Zaleta, A.K., Hevelone, N.D., Rosas, H.D., Choice reaction time performance correlates with diffusion anisotropy in white matter pathways supporting visuospatial attention (2005) Proceedings of the National Academy of Sciences of the United States of America, 102 (34), pp. 12212-12217. , DOI 10.1073/pnas.0407259102; Wolbers, T., Schoell, E.D., Verleger, R., Kraft, S., McNamara, A., Jaskowski, P., Buchel, C., Changes in connectivity profiles as a mechanism for strategic control over interfering subliminal information (2006) Cerebral Cortex, 16 (6), pp. 857-864. , DOI 10.1093/cercor/bhj029; Johansen-Berg, H., Della-Maggiore, V., Behrens, T.E.J., Smith, S.M., Paus, T., Integrity of white matter in the corpus callosum correlates with bimanual co-ordination skills (2007) NeuroImage, 36 (SUPPL. 2), pp. T16-T21. , DOI 10.1016/j.neuroimage.2007.03.041, PII S1053811907002388; Roberts, R.E., Anderson, E.J., Husain, M., White matter microstructure and cognitive function (2013) Neuroscientist, 19, pp. 8-15; Wahl, M., Lauterbach-Soon, B., Hattingen, E., Jung, P., Singer, O., Volz, S., Klein, J.C., Ziemann, U., Human motor corpus callosum: Topography, somatotopy, and link between microstructure and function (2007) Journal of Neuroscience, 27 (45), pp. 12132-12138. , http://www.jneurosci.org/cgi/reprint/27/45/12132, DOI 10.1523/JNEUROSCI.2320-07.2007; Kl{\"o}ppel, S., B{\"a}umer, T., Kroeger, J., Koch, M.A., B{\"u}chel, C., The cortical motor threshold reflects microstructural properties of cerebral white matter (2008) Neuroimage, 40, pp. 1782-7991; Malcolm, M.P., Triggs, W.J., Light, K.E., Shechtman, O., Khandekar, G., Reliability of motor cortex transcranial magnetic stimulation in four muscle representations (2006) Clin Neurophysiol, 117, pp. 1037-1046; Tazoe, T., Endoh, T., Nakajima, T., Sakamoto, M., Komiyama, T., Disinhibition of upper limb motor area by voluntary contraction of the lower limb muscle (2007) Experimental Brain Research, 177 (3), pp. 419-430. , DOI 10.1007/s00221-006-0686-1; Rossini, P.M., Barker, A.T., Berardelli, A., Caramia, M.D., Caruso, G., Cracco, R.Q., Dimitrijevic, M.R., Tomberg, C., Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: Basic principles and procedures for routine clinical application. Report of an IFCN committee (1994) Electroencephalography and Clinical Neurophysiology, 91 (2), pp. 79-92. , DOI 10.1016/0013-4694(94)90029-9; Kamen, G., Reliability of motor-evoked potentials during resting and active contraction conditions (2004) Med Sci Sports Exerc, 36, pp. 1574-1579; Christie, A., Fling, B., Crews, R.T., Mulwitz, L.A., Kamen, G., Reliability of motor-evoked potentials in the ADM muscle of older adults (2007) Journal of Neuroscience Methods, 164 (2), pp. 320-324. , DOI 10.1016/j.jneumeth.2007.05.011, PII S0165027007002257; Doeltgen, S.H., Ridding, M.C., O'Beirne, G.A., Dalrymple-Alford, J., Huckabee, M.L., Test-retest reliability of motor evoked potentials (MEPs) at the submental muscle group during volitional swallowing (2009) J Neurosci Methods, 178, pp. 134-137; Kiebel, S., Holmes, A., The general linear model (2003) Human Brain Function, 2nd Edition, pp. 725-761. , Frackowiak RS, Friston K, Frith CD, Dolan RJ, Price CJ, Zeki S, Ashburner J, Penny W, editors San Diego: Elsevier Academic Press; Debaere, F., Wenderoth, N., Sunaert, S., Van Hecke, P., Swinnen, S.P., Internal vs external generation of movements: Differential neural pathways involved in bimanual coordination performed in the presence or absence of augmented visual feedback (2003) NeuroImage, 19 (3), pp. 764-776. , DOI 10.1016/S1053-8119(03)00148-4; Van Dijk, K.R., Sabuncu, M.R., Buckner, R.L., The influence of head motion on intrinsic functional connectivity MRI (2012) Neuroimage, 59, pp. 431-438; Jenkinson, M., Smith, S., A global optimisation method for robust affine registration of brain images (2001) Medical Image Analysis, 5 (2), pp. 143-156. , DOI 10.1016/S1361-8415(01)00036-6, PII S1361841501000366; Behrens, T.E.J., Woolrich, M.W., Jenkinson, M., Johansen-Berg, H., Nunes, R.G., Clare, S., Matthews, P.M., Smith, S.M., Characterization and Propagation of Uncertainty in Diffusion-Weighted MR Imaging (2003) Magnetic Resonance in Medicine, 50 (5), pp. 1077-1088. , DOI 10.1002/mrm.10609; Oguri, T., Sawamoto, N., Tabu, H., Urayama, S., Matsuhashi, M., Overlapping connections within the motor cortico-basal ganglia circuit: FMRI-tractography analysis (2013) Neuroimage, 78, pp. 353-362; Thomalla, G., Jonas, M., B{\"a}umer, T., Siebner, H.R., Biermann-Ruben, K., Costs of control: Decreased motor cortex engagement during a Go/NoGo task in Tourette's syndrome (2014) Brain, 137, pp. 122-136; Behrens, T.E.J., Johansen-Berg, H., Woolrich, M.W., Smith, S.M., Wheeler-Kingshott, C.A.M., Boulby, P.A., Barker, G.J., Matthews, P.M., Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging (2003) Nature Neuroscience, 6 (7), pp. 750-757. , DOI 10.1038/nn1075; Behrens, T.E.J., Berg, H.J., Jbabdi, S., Rushworth, M.F.S., Woolrich, M.W., Probabilistic diffusion tractography with multiple fibre orientations: What can we gain? (2007) NeuroImage, 34 (1), pp. 144-155. , DOI 10.1016/j.neuroimage.2006.09.018, PII S1053811906009360; Aboitiz, F., Scheibel, A.B., Fisher, R.S., Zaidel, E., Fiber composition of the human corpus callosum (1992) Brain Research, 598 (1-2), pp. 143-153. , DOI 10.1016/0006-8993(92)90178-C; Hofer, S., Frahm, J., Topography of the human corpus callosum revisited-Comprehensive fiber tractography using diffusion tensor magnetic resonance imaging (2006) NeuroImage, 32 (3), pp. 989-994. , DOI 10.1016/j.neuroimage.2006.05.044, PII S1053811906006501; Zarei, M., Johansen-Berg, H., Smith, S., Ciccarelli, O., Thompson, A.J., Matthews, P.M., Functional anatomy of interhemispheric cortical connections in the human brain (2006) Journal of Anatomy, 209 (3), pp. 311-320. , DOI 10.1111/j.1469-7580.2006.00615.x; Hubers, A., Klein, J.C., Kang, J.S., Hilker, R., Ziemann, U., The relationship between TMS measures of functional properties and DTI measures of microstructure of the corticospinal tract (2012) Brain Stimul, 5, pp. 297-304",
year = "2014",
doi = "10.1371/journal.pone.0104218",
language = "English",
volume = "9",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

TY - JOUR

T1 - Fractional anisotropy in corpus callosum is associated with facilitation of motor representation during ipsilateral hand movements

AU - Chiou, Shin-Yi

AU - Wang, Ray-Yau

AU - Roberts, Richard Edward

AU - Wu, Yu-Te

AU - Lu, Chia-Feng

AU - Liao, Kwong-Kum

AU - Yang, Yea-Ru

N1 - Export Date: 31 March 2016 CODEN: POLNC 參考文獻: Stippich, C., Blatow, M., Durst, A., Dreyhaupt, J., Sartor, K., Global activation of primary motor cortex during voluntary movements in man (2007) NeuroImage, 34 (3), pp. 1227-1237. , DOI 10.1016/j.neuroimage.2006.08.046, PII S1053811906008834; Chiou, S.Y., Wang, R.Y., Liao, K.K., Yang, Y.R., Homologous muscle contraction during unilateral movement does not show a dominant effect on leg representation of the ipsilateral primary motor cortex (2013) PLoS One, 8, pp. e72231; Chiou, S.Y., Wang, R.Y., Liao, K.K., Wu, Y.T., Lu, C.F., Co-activation of primary motor cortex ipsilateral to muscles contracting in a unilateral motor task (2013) Clin Neurophysiol, 124, pp. 1353-1363; Hess, C.W., Hunziker, T., Kupfer, A., Ludin, H.P., Thalidomide-induced peripheral neuropathy. A prospective clinical, neurophysiological and pharmacogenetic evaluation (1986) Journal of Neurology, 233 (2), pp. 83-89; Meyer, B.U., Röricht, S., Gräfin Von Einsiedel, H., Kruggel, F., Weindl, A., Inhibitory and excitatory interhemispheric transfers between motor cortical areas in normal humans and patients with abnormalities of the corpus callosum (1995) Brain, 118, pp. 429-440; Stedman, A., Davey, N.J., Ellaway, P.H., Facilitation of human first dorsal interosseous muscle responses to transcranial magnetic stimulation during voluntary contraction of the contralateral homonymous muscle (1998) Muscle and Nerve, 21 (8), pp. 1033-1039. , DOI 10.1002/(SICI)1097-4598(199808)21:8<1033::AID; Tinazzi, M., Zanette, G., Modulation of ipsilateral motor cortex in man during unimanual finger movements of different complexities (1998) Neuroscience Letters, 244 (3), pp. 121-124. , DOI 10.1016/S0304-3940(98)00150-5; Muellbacher, W., Facchini, S., Boroojerdi, B., Hallett, M., Changes in motor cortex excitability during ipsilateral hand muscle activation in humans (2000) Clinical Neurophysiology, 111 (2), pp. 344-349. , DOI 10.1016/S1388-2457(99)00243-6, PII S1388245799002436; Hortobagyi, T., Taylor, J.L., Petersen, N.T., Russell, G., Gandevia, S.C., Changes in segmental and motor cortical output with contralateral muscle contractions and altered sensory inputs in humans (2003) Journal of Neurophysiology, 90 (4), pp. 2451-2459. , DOI 10.1152/jn.01001.2002; Chen, R., Interactions between inhibitory and excitatory circuits in the human motor cortex (2004) Exp Brain Res, 154, pp. 1-10; Harris-Love, M.L., Perez, M.A., Chen, R., Cohen, L.G., Interhemispheric inhibition in distal and proximal arm representations in the primary motor cortex (2007) Journal of Neurophysiology, 97 (3), pp. 2511-2515. , http://jn.physiology.org/cgi/reprint/97/3/2511, DOI 10.1152/jn.01331.2006; Perez, M.A., Cohen, L.G., Mechanisms underlying functional changes in the primary motor cortex ipsilateral to an active hand (2008) J Neurosci, 28, pp. 5631-5640; Hortobágyi, T., Richardson, S.P., Lomarev, M., Shamim, E., Meunier, S., Interhemispheric plasticity in humans (2011) Med Sci Sports Exerc, 43, pp. 1188-1199; Stinear, C.M., Walker, K.S., Byblow, W.D., Symmetric facilitation between motor cortices during contraction of ipsilateral hand muscles (2001) Experimental Brain Research, 139 (1), pp. 101-105. , DOI 10.1007/s002210100758; Carson, R.G., Neural pathways mediating bilateral interactions between the upper limbs (2005) Brain Res Brain Res Rev, 49, pp. 641-662; Beaulieu, C., The basis of anisotropic water diffusion in the nervous system - A technical review (2002) NMR Biomed, 15, pp. 435-455; Moseley, M.E., Cohen, Y., Mintorovitch, J., Chileuitt, L., Shimizu, H., Kucharczyk, J., Wendland, M.F., Weinstein, P.R., Early detection of regional cerebral ischemia in cats: Comparison of diffusion- and T2-weighted MRI and spectroscopy (1990) Magnetic Resonance in Medicine, 14 (2), pp. 330-346. , DOI 10.1002/mrm.1910140218; Le Bihan, D., Looking into the functional architecture of the brain with diffusion MRI (2003) Nat Rev Neurosci, 4, pp. 469-480; Le, B.D., Mangin, J.-F., Poupon, C., Clark, C.A., Pappata, S., Molko, N., Chabriat, H., Diffusion tensor imaging: Concepts and applications (2001) Journal of Magnetic Resonance Imaging, 13 (4), pp. 534-546. , DOI 10.1002/jmri.1076; Pfefferbaum, A., Adalsteinsson, E., Sullivan, E.V., Replicability of diffusion tensor imaging measurements of fractional anisotropy and trace in brain (2003) Journal of Magnetic Resonance Imaging, 18 (4), pp. 427-433. , DOI 10.1002/jmri.10377; Madden, D.J., Whiting, W.L., Huettel, S.A., White, L.E., MacFall, J.R., Provenzale, J.M., Diffusion tensor imaging of adult age differences in cerebral white matter: Relation to response time (2004) NeuroImage, 21 (3), pp. 1174-1181. , DOI 10.1016/j.neuroimage.2003.11.004, PII S1053811903007249; Deutsch, G.K., Dougherty, R.F., Bammer, R., Siok, W.T., Gabrieli, J.D.E., Wandell, B., Children's reading performance is correlated with white matter structure measured by diffusion tensor imaging (2005) Cortex, 41 (3), pp. 354-363; Schulte, T., Sullivan, E.V., Muller-Oehring, E.M., Adalsteinsson, E., Pfefferbaum, A., Corpus callosal microstructural integrity influences interhemispheric processing: A diffusion tensor imaging study (2005) Cerebral Cortex, 15 (9), pp. 1384-1392. , DOI 10.1093/cercor/bhi020; Tuch, D.S., Salat, D.H., Wisco, J.J., Zaleta, A.K., Hevelone, N.D., Rosas, H.D., Choice reaction time performance correlates with diffusion anisotropy in white matter pathways supporting visuospatial attention (2005) Proceedings of the National Academy of Sciences of the United States of America, 102 (34), pp. 12212-12217. , DOI 10.1073/pnas.0407259102; Wolbers, T., Schoell, E.D., Verleger, R., Kraft, S., McNamara, A., Jaskowski, P., Buchel, C., Changes in connectivity profiles as a mechanism for strategic control over interfering subliminal information (2006) Cerebral Cortex, 16 (6), pp. 857-864. , DOI 10.1093/cercor/bhj029; Johansen-Berg, H., Della-Maggiore, V., Behrens, T.E.J., Smith, S.M., Paus, T., Integrity of white matter in the corpus callosum correlates with bimanual co-ordination skills (2007) NeuroImage, 36 (SUPPL. 2), pp. T16-T21. , DOI 10.1016/j.neuroimage.2007.03.041, PII S1053811907002388; Roberts, R.E., Anderson, E.J., Husain, M., White matter microstructure and cognitive function (2013) Neuroscientist, 19, pp. 8-15; Wahl, M., Lauterbach-Soon, B., Hattingen, E., Jung, P., Singer, O., Volz, S., Klein, J.C., Ziemann, U., Human motor corpus callosum: Topography, somatotopy, and link between microstructure and function (2007) Journal of Neuroscience, 27 (45), pp. 12132-12138. , http://www.jneurosci.org/cgi/reprint/27/45/12132, DOI 10.1523/JNEUROSCI.2320-07.2007; Klöppel, S., Bäumer, T., Kroeger, J., Koch, M.A., Büchel, C., The cortical motor threshold reflects microstructural properties of cerebral white matter (2008) Neuroimage, 40, pp. 1782-7991; Malcolm, M.P., Triggs, W.J., Light, K.E., Shechtman, O., Khandekar, G., Reliability of motor cortex transcranial magnetic stimulation in four muscle representations (2006) Clin Neurophysiol, 117, pp. 1037-1046; Tazoe, T., Endoh, T., Nakajima, T., Sakamoto, M., Komiyama, T., Disinhibition of upper limb motor area by voluntary contraction of the lower limb muscle (2007) Experimental Brain Research, 177 (3), pp. 419-430. , DOI 10.1007/s00221-006-0686-1; Rossini, P.M., Barker, A.T., Berardelli, A., Caramia, M.D., Caruso, G., Cracco, R.Q., Dimitrijevic, M.R., Tomberg, C., Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: Basic principles and procedures for routine clinical application. Report of an IFCN committee (1994) Electroencephalography and Clinical Neurophysiology, 91 (2), pp. 79-92. , DOI 10.1016/0013-4694(94)90029-9; Kamen, G., Reliability of motor-evoked potentials during resting and active contraction conditions (2004) Med Sci Sports Exerc, 36, pp. 1574-1579; Christie, A., Fling, B., Crews, R.T., Mulwitz, L.A., Kamen, G., Reliability of motor-evoked potentials in the ADM muscle of older adults (2007) Journal of Neuroscience Methods, 164 (2), pp. 320-324. , DOI 10.1016/j.jneumeth.2007.05.011, PII S0165027007002257; Doeltgen, S.H., Ridding, M.C., O'Beirne, G.A., Dalrymple-Alford, J., Huckabee, M.L., Test-retest reliability of motor evoked potentials (MEPs) at the submental muscle group during volitional swallowing (2009) J Neurosci Methods, 178, pp. 134-137; Kiebel, S., Holmes, A., The general linear model (2003) Human Brain Function, 2nd Edition, pp. 725-761. , Frackowiak RS, Friston K, Frith CD, Dolan RJ, Price CJ, Zeki S, Ashburner J, Penny W, editors San Diego: Elsevier Academic Press; Debaere, F., Wenderoth, N., Sunaert, S., Van Hecke, P., Swinnen, S.P., Internal vs external generation of movements: Differential neural pathways involved in bimanual coordination performed in the presence or absence of augmented visual feedback (2003) NeuroImage, 19 (3), pp. 764-776. , DOI 10.1016/S1053-8119(03)00148-4; Van Dijk, K.R., Sabuncu, M.R., Buckner, R.L., The influence of head motion on intrinsic functional connectivity MRI (2012) Neuroimage, 59, pp. 431-438; Jenkinson, M., Smith, S., A global optimisation method for robust affine registration of brain images (2001) Medical Image Analysis, 5 (2), pp. 143-156. , DOI 10.1016/S1361-8415(01)00036-6, PII S1361841501000366; Behrens, T.E.J., Woolrich, M.W., Jenkinson, M., Johansen-Berg, H., Nunes, R.G., Clare, S., Matthews, P.M., Smith, S.M., Characterization and Propagation of Uncertainty in Diffusion-Weighted MR Imaging (2003) Magnetic Resonance in Medicine, 50 (5), pp. 1077-1088. , DOI 10.1002/mrm.10609; Oguri, T., Sawamoto, N., Tabu, H., Urayama, S., Matsuhashi, M., Overlapping connections within the motor cortico-basal ganglia circuit: FMRI-tractography analysis (2013) Neuroimage, 78, pp. 353-362; Thomalla, G., Jonas, M., Bäumer, T., Siebner, H.R., Biermann-Ruben, K., Costs of control: Decreased motor cortex engagement during a Go/NoGo task in Tourette's syndrome (2014) Brain, 137, pp. 122-136; Behrens, T.E.J., Johansen-Berg, H., Woolrich, M.W., Smith, S.M., Wheeler-Kingshott, C.A.M., Boulby, P.A., Barker, G.J., Matthews, P.M., Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging (2003) Nature Neuroscience, 6 (7), pp. 750-757. , DOI 10.1038/nn1075; Behrens, T.E.J., Berg, H.J., Jbabdi, S., Rushworth, M.F.S., Woolrich, M.W., Probabilistic diffusion tractography with multiple fibre orientations: What can we gain? (2007) NeuroImage, 34 (1), pp. 144-155. , DOI 10.1016/j.neuroimage.2006.09.018, PII S1053811906009360; Aboitiz, F., Scheibel, A.B., Fisher, R.S., Zaidel, E., Fiber composition of the human corpus callosum (1992) Brain Research, 598 (1-2), pp. 143-153. , DOI 10.1016/0006-8993(92)90178-C; Hofer, S., Frahm, J., Topography of the human corpus callosum revisited-Comprehensive fiber tractography using diffusion tensor magnetic resonance imaging (2006) NeuroImage, 32 (3), pp. 989-994. , DOI 10.1016/j.neuroimage.2006.05.044, PII S1053811906006501; Zarei, M., Johansen-Berg, H., Smith, S., Ciccarelli, O., Thompson, A.J., Matthews, P.M., Functional anatomy of interhemispheric cortical connections in the human brain (2006) Journal of Anatomy, 209 (3), pp. 311-320. , DOI 10.1111/j.1469-7580.2006.00615.x; Hubers, A., Klein, J.C., Kang, J.S., Hilker, R., Ziemann, U., The relationship between TMS measures of functional properties and DTI measures of microstructure of the corticospinal tract (2012) Brain Stimul, 5, pp. 297-304

PY - 2014

Y1 - 2014

N2 - Background: Coactivation of primary motor cortex ipsilateral to a unilateral movement (M1ipsilateral) has been observed, and the magnitude of activation is influenced by the contracting muscles. It has been suggested that the microstructural integrity of the callosal motor fibers (CMFs) connecting M1 regions may reflect the observed response. However, the association between the structural connectivity of CMFs and functional changes in M1ipsilateral remains unclear. The purpose of this study was to investigate the relationship between functional changes within M1 ipsilateral during unilateral arm or leg movements and the microstructure of the CMFs connecting both homotopic representations (arm or leg). Methods: Transcranial magnetic stimulation was used to assess changes in motor evoked potentials (MEP) in an arm muscle during unilateral movements compared to rest in fifteen healthy adults. Functional magnetic resonance imaging was then used to identify regions of M1 associated with either arm or leg movements. Diffusion-weighted imaging data was acquired to generate CMFs for arm and leg areas using the areas of activation from the functional imaging as seed masks. Individual values of regional fractional anisotropy (FA) of arm and leg CMFs was then calculated by examining the overlap between CMFs and a standard atlas of corpus callosum. Results: The change in the MEP was significantly larger in the arm movement compared to the leg movement. Additionally, regression analysis revealed that FA in the arm CMFs was positively correlated with the change in MEP during arm movement, whereas a negative correlation was observed during the leg movement. However, there was no significant relationship between FA in the leg CMF and the change in MEP during the movements. Conclusions: These findings suggest that individual differences in interhemispheric structural connectivity may be used to explain a homologous muscle-dominant effect within M1ipsilateral hand representation during unilateral movement with topographical specificity. © 2014 Chiou et al.

AB - Background: Coactivation of primary motor cortex ipsilateral to a unilateral movement (M1ipsilateral) has been observed, and the magnitude of activation is influenced by the contracting muscles. It has been suggested that the microstructural integrity of the callosal motor fibers (CMFs) connecting M1 regions may reflect the observed response. However, the association between the structural connectivity of CMFs and functional changes in M1ipsilateral remains unclear. The purpose of this study was to investigate the relationship between functional changes within M1 ipsilateral during unilateral arm or leg movements and the microstructure of the CMFs connecting both homotopic representations (arm or leg). Methods: Transcranial magnetic stimulation was used to assess changes in motor evoked potentials (MEP) in an arm muscle during unilateral movements compared to rest in fifteen healthy adults. Functional magnetic resonance imaging was then used to identify regions of M1 associated with either arm or leg movements. Diffusion-weighted imaging data was acquired to generate CMFs for arm and leg areas using the areas of activation from the functional imaging as seed masks. Individual values of regional fractional anisotropy (FA) of arm and leg CMFs was then calculated by examining the overlap between CMFs and a standard atlas of corpus callosum. Results: The change in the MEP was significantly larger in the arm movement compared to the leg movement. Additionally, regression analysis revealed that FA in the arm CMFs was positively correlated with the change in MEP during arm movement, whereas a negative correlation was observed during the leg movement. However, there was no significant relationship between FA in the leg CMF and the change in MEP during the movements. Conclusions: These findings suggest that individual differences in interhemispheric structural connectivity may be used to explain a homologous muscle-dominant effect within M1ipsilateral hand representation during unilateral movement with topographical specificity. © 2014 Chiou et al.

KW - adult

KW - anisotropy

KW - brain mapping

KW - corpus callosum

KW - diffusion weighted imaging

KW - evoked muscle response

KW - female

KW - hand

KW - hemispheric dominance

KW - human

KW - leg

KW - male

KW - motor cortex

KW - muscle contraction

KW - nuclear magnetic resonance imaging

KW - physiology

KW - psychomotor performance

KW - regression analysis

KW - transcranial magnetic stimulation

KW - Adult

KW - Anisotropy

KW - Brain Mapping

KW - Corpus Callosum

KW - Diffusion Magnetic Resonance Imaging

KW - Evoked Potentials, Motor

KW - Female

KW - Functional Laterality

KW - Hand

KW - Humans

KW - Leg

KW - Magnetic Resonance Imaging

KW - Male

KW - Motor Cortex

KW - Muscle Contraction

KW - Psychomotor Performance

KW - Regression Analysis

KW - Transcranial Magnetic Stimulation

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84905965750&partnerID=40&md5=94e6059a84de014d05fa541c3b914f57

UR - https://www.scopus.com/results/citedbyresults.uri?sort=plf-f&cite=2-s2.0-84905965750&src=s&imp=t&sid=78cccaecf7506c61c3f1e924fe82e1b0&sot=cite&sdt=a&sl=0&origin=recordpage&editSaveSearch=&txGid=230533b47135a2129a38c0e44df2706c

U2 - 10.1371/journal.pone.0104218

DO - 10.1371/journal.pone.0104218

M3 - Article

VL - 9

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 8

ER -