Foxp1 and Lhx1 coordinate motor neuron migration with axon trajectory choice by gating reelin signalling

Elena Palmesino, David L. Rousso, Tzu Jen Kao, Avihu Klar, Ed Laufer, Osamu Uemura, Hitoshi Okamoto, Bennett G. Novitch, Artur Kania

研究成果: 雜誌貢獻文章

60 引文 斯高帕斯(Scopus)

摘要

Topographic neuronal maps arise as a consequence of axon trajectory choice correlated with the localisation of neuronal soma, but the identity of the pathways coordinating these processes is unknown. We addressed this question in the context of the myotopic map formed by limb muscles innervated by spinal lateral motor column (LMC) motor axons where the Eph receptor signals specifying growth cone trajectory are restricted by Foxp1 and Lhx1 transcription factors. We show that the localisation of LMC neuron cell bodies can be dissociated from axon trajectory choice by either the loss or gain of function of the Reelin signalling pathway. The response of LMC motor neurons to Reelin is gated by Foxp1- and Lhx1-mediated regulation of expression of the critical Reelin signalling intermediate Dab1. Together, these observations point to identical transcription factors that control motor axon guidance and soma migration and reveal the molecular hierarchy of myotopic organisation.
原文英語
頁(從 - 到)41-42
頁數2
期刊PLoS Biology
8
發行號8
DOIs
出版狀態已發佈 - 八月 2010
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)

引用此

Palmesino, E., Rousso, D. L., Kao, T. J., Klar, A., Laufer, E., Uemura, O., Okamoto, H., Novitch, B. G., & Kania, A. (2010). Foxp1 and Lhx1 coordinate motor neuron migration with axon trajectory choice by gating reelin signalling. PLoS Biology, 8(8), 41-42. https://doi.org/10.1371/journal.pbio.1000446