Formulation and evaluation of diclofenac sodium gel by using natural polymer

Naresh Ahuja, Vipin Saini, Vijay Kumar Bishnoi, Atul Garg, Monika Hisoria, Joyati Sharma, Kunal Nepali

研究成果: 雜誌貢獻文章同行評審

13 引文 斯高帕斯(Scopus)

摘要

A major problem being faced in ocular therapeutic is the attainment of an optimal concentration at the site of action1. The bioavailability of diclofenac sodium in the form of eye drop is very low and when the drug is administered in the form of ophthalmic suspension it lead to irritation due to particle size. So in the present study diclofenac sodium gels were developed with the aim of promoting the prolong release of drug using natural polymer. Diclofenac sodium gels were sterilized and assessed for various parameters like clarity, viscosity, pH, extrudability and sterility. In -vitro drug release determined using dialysis membrane in phosphate buffer pH 7. 4. Ocular irritation studies were performed on albino rabbits.
原文英語
頁(從 - 到)564-566
頁數3
期刊Rasayan Journal of Chemistry
1
發行號3
出版狀態已發佈 - 一月 1 2008
對外發佈

ASJC Scopus subject areas

  • 化學 (全部)
  • 生物化學
  • 化學工程 (全部)
  • 藥理學、毒理學和藥劑學 (全部)
  • 能源(全部)

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