Focal seizures as an unusual presentation of neonatal lupus erythematosus

Sheng-Chieh Lin, Shyh-Dar Shyur, Li-Hsin Huang, Jiunn-Yi Wu, Yi-Chun Ma

研究成果: 雜誌貢獻文章

11 引文 (Scopus)

摘要

Neonatal lupus erythematosus is an uncommon passive autoimmune disease in which there is a transplacental passage of anti-Ro/SSA and/or anti-La/SSB maternal autoantibodies. Common clinical manifestations include cardiac disease, notably congenital heart block, cutaneous lupus lesions, hematologic disorders, and hepatobiliary disease. During the past decade, however, it has become clear that central nervous disease may also be a manifestation of neonatal lupus. We report a male neonate with the disease who had focal seizures in addition to cutaneous lupus, anemia, and thrombocytopenia. Brain ultrasound revealed normal ventricular size without a midline shift or intracranial or intraventricular hemorrhage. A brain CT showed generalized low density involving the periventricular and deep white matter. A sleep EEG revealed rare spikes axial to the right parietal lobe. The neonate had a high titer of antinuclear antibodies (1:640) with a speckled pattern, anti-Ro/SSA and anti-La/SSB antibodies, but no anti-dsDNA antibodies. He was given anti-convulsant drugs with dramatic improvement of his symptoms. One month later, a sleep EEG was normal, and he had no further seizures.
原文英語
頁(從 - 到)61-64
頁數4
期刊Asian Pacific Journal of Allergy and Immunology
23
發行號1
出版狀態已發佈 - 2005
對外發佈Yes

指紋

Seizures
Electroencephalography
Sleep
Convulsants
Skin
Parietal Lobe
Antinuclear Antibodies
Brain
Thrombocytopenia
Autoantibodies
Autoimmune Diseases
Anemia
Anti-Idiotypic Antibodies
Heart Diseases
Mothers
Hemorrhage
Antibodies
Pharmaceutical Preparations
Neonatal Systemic lupus erythematosus
Congenital heart block

引用此文

Focal seizures as an unusual presentation of neonatal lupus erythematosus. / Lin, Sheng-Chieh; Shyur, Shyh-Dar; Huang, Li-Hsin; Wu, Jiunn-Yi; Ma, Yi-Chun.

於: Asian Pacific Journal of Allergy and Immunology, 卷 23, 編號 1, 2005, p. 61-64.

研究成果: 雜誌貢獻文章

Lin, Sheng-Chieh ; Shyur, Shyh-Dar ; Huang, Li-Hsin ; Wu, Jiunn-Yi ; Ma, Yi-Chun. / Focal seizures as an unusual presentation of neonatal lupus erythematosus. 於: Asian Pacific Journal of Allergy and Immunology. 2005 ; 卷 23, 編號 1. 頁 61-64.
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title = "Focal seizures as an unusual presentation of neonatal lupus erythematosus",
abstract = "Neonatal lupus erythematosus is an uncommon passive autoimmune disease in which there is a transplacental passage of anti-Ro/SSA and/or anti-La/SSB maternal autoantibodies. Common clinical manifestations include cardiac disease, notably congenital heart block, cutaneous lupus lesions, hematologic disorders, and hepatobiliary disease. During the past decade, however, it has become clear that central nervous disease may also be a manifestation of neonatal lupus. We report a male neonate with the disease who had focal seizures in addition to cutaneous lupus, anemia, and thrombocytopenia. Brain ultrasound revealed normal ventricular size without a midline shift or intracranial or intraventricular hemorrhage. A brain CT showed generalized low density involving the periventricular and deep white matter. A sleep EEG revealed rare spikes axial to the right parietal lobe. The neonate had a high titer of antinuclear antibodies (1:640) with a speckled pattern, anti-Ro/SSA and anti-La/SSB antibodies, but no anti-dsDNA antibodies. He was given anti-convulsant drugs with dramatic improvement of his symptoms. One month later, a sleep EEG was normal, and he had no further seizures.",
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author = "Sheng-Chieh Lin and Shyh-Dar Shyur and Li-Hsin Huang and Jiunn-Yi Wu and Yi-Chun Ma",
note = "被引用次數:7 Export Date: 7 April 2016 CODEN: APJIE 通訊地址: Shyur, S.-D.; Division of Allergy and Immunology, Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan; 電子郵件: abc1016@ms2.mmh.org.tw 化學物質/CAS: phenobarbital, 50-06-6, 57-30-7, 8028-68-0; phenytoin, 57-41-0, 630-93-3; Anticonvulsants; Autoantigens; Phenytoin, 57-41-0; Ribonucleoproteins; SS-A antigen; SS-B antigen 參考文獻: Cabral, D.A., Mehta, S., Julie, P., Michael, S., Abnormal central nervous system (CNS) imaging studies in neonatal lupus erythematosus (NLE) (1999) Arthritis Rheum., 42 (SUPPL.), pp. S180; Prendiville, J.S., Cabral, D.A., Poskitt, K.J., Au, S., Sargent, M.A., Central nervous system involvement in neonatal lupus erythematosus (2003) Pediatr. Dermatol., 20, pp. 60-67; Burch, J.M., Lee, L.A., Weston, W.L., Neonatal lupus erythematosus (2002) Dermatol. Nur., 14, pp. 157-160; Le Thi Houng, D., Wechsler, B., Piette, J.C., Bletry, O., Godean, P., Pregnancy and its outcome in systemic lupus erythematosus (1994) QJ Med., 87, pp. 721-729; Kim, J., Smith, K.J., Skelton, H., Neonatal lupus erythematosus: Factors which may lead to clinical disease in the foetus even in the absence of disease in the mother (2001) Clin. Exp. Dermatol., 26, pp. 423-426; Kaye, E.M., Butler, I.J., Conley, S., Myelopathy in neonatal and infantile lupus erythematosus (1987) J. Neurol. Neurosurg. Psychiatry, 50, pp. 923-926; Dorner, T., Feist, E., Pruss, A., Chaoui, R., Goldner, B., Hiepe, F., Significance of autoantibodies in neonatal lupus erythematosus (2000) Int. Arch. Allergy Immunol., 123, pp. 58-66; Cabanas, F., Pellicer, A., Valverde, E., Morales, C., Quero, J., Central nervous system vasculopathy in neonatal lupus erythematosus (1996) Pediatr. Neurol., 15, pp. 124-126; Weston, W.L., Morelli, J.G., Lee, L.A., The clinical spectrum of anti-Ro-positive cutaneous neonatal lupus erythematosus (1999) J. Am. Acad. Dermatol., 40, pp. 675-681; Provost, T.T., Vasily, D., Alexander, E., Sjogren's syndrome: Cutaneous, immunologic, and nervous system manifestations (1987) Neurol. Clin., 5, pp. 405-426; Besson-L{\'e}aud, L., Fontan, D., Billeaud, C., Sandier, B., Neonatal lupus erythematosus and neurologic involvement: An incidental association? (2002) Arch. Pediatr., 9, pp. 503-505; Nakayama-Furukawa, F., Takigawa, M., Iwatsuki, K., Sato, N., Sato, H., Hydrocephalus in two female siblings with neonatal lupus erythematosus (1994) Arch. Dermatol., 130, pp. 1210-1212; Bourke, J.F., Burns, D.A., Neonatal lupus erythematosus with persistent Telangiectasia and spastic paraparesis (1993) Clin. Exp. Dermatol., 18, pp. 271-273; Inoue, K., Fukushige, J., Ohno, T., Igarashi, H., Hara, T., Central nervous system vasculopathy associated with neonatal lupus (2002) Pediatr. Neurol., 26, pp. 68-70",
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TY - JOUR

T1 - Focal seizures as an unusual presentation of neonatal lupus erythematosus

AU - Lin, Sheng-Chieh

AU - Shyur, Shyh-Dar

AU - Huang, Li-Hsin

AU - Wu, Jiunn-Yi

AU - Ma, Yi-Chun

N1 - 被引用次數:7 Export Date: 7 April 2016 CODEN: APJIE 通訊地址: Shyur, S.-D.; Division of Allergy and Immunology, Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan; 電子郵件: abc1016@ms2.mmh.org.tw 化學物質/CAS: phenobarbital, 50-06-6, 57-30-7, 8028-68-0; phenytoin, 57-41-0, 630-93-3; Anticonvulsants; Autoantigens; Phenytoin, 57-41-0; Ribonucleoproteins; SS-A antigen; SS-B antigen 參考文獻: Cabral, D.A., Mehta, S., Julie, P., Michael, S., Abnormal central nervous system (CNS) imaging studies in neonatal lupus erythematosus (NLE) (1999) Arthritis Rheum., 42 (SUPPL.), pp. S180; Prendiville, J.S., Cabral, D.A., Poskitt, K.J., Au, S., Sargent, M.A., Central nervous system involvement in neonatal lupus erythematosus (2003) Pediatr. Dermatol., 20, pp. 60-67; Burch, J.M., Lee, L.A., Weston, W.L., Neonatal lupus erythematosus (2002) Dermatol. Nur., 14, pp. 157-160; Le Thi Houng, D., Wechsler, B., Piette, J.C., Bletry, O., Godean, P., Pregnancy and its outcome in systemic lupus erythematosus (1994) QJ Med., 87, pp. 721-729; Kim, J., Smith, K.J., Skelton, H., Neonatal lupus erythematosus: Factors which may lead to clinical disease in the foetus even in the absence of disease in the mother (2001) Clin. Exp. Dermatol., 26, pp. 423-426; Kaye, E.M., Butler, I.J., Conley, S., Myelopathy in neonatal and infantile lupus erythematosus (1987) J. Neurol. Neurosurg. Psychiatry, 50, pp. 923-926; Dorner, T., Feist, E., Pruss, A., Chaoui, R., Goldner, B., Hiepe, F., Significance of autoantibodies in neonatal lupus erythematosus (2000) Int. Arch. Allergy Immunol., 123, pp. 58-66; Cabanas, F., Pellicer, A., Valverde, E., Morales, C., Quero, J., Central nervous system vasculopathy in neonatal lupus erythematosus (1996) Pediatr. Neurol., 15, pp. 124-126; Weston, W.L., Morelli, J.G., Lee, L.A., The clinical spectrum of anti-Ro-positive cutaneous neonatal lupus erythematosus (1999) J. Am. Acad. Dermatol., 40, pp. 675-681; Provost, T.T., Vasily, D., Alexander, E., Sjogren's syndrome: Cutaneous, immunologic, and nervous system manifestations (1987) Neurol. Clin., 5, pp. 405-426; Besson-Léaud, L., Fontan, D., Billeaud, C., Sandier, B., Neonatal lupus erythematosus and neurologic involvement: An incidental association? (2002) Arch. Pediatr., 9, pp. 503-505; Nakayama-Furukawa, F., Takigawa, M., Iwatsuki, K., Sato, N., Sato, H., Hydrocephalus in two female siblings with neonatal lupus erythematosus (1994) Arch. Dermatol., 130, pp. 1210-1212; Bourke, J.F., Burns, D.A., Neonatal lupus erythematosus with persistent Telangiectasia and spastic paraparesis (1993) Clin. Exp. Dermatol., 18, pp. 271-273; Inoue, K., Fukushige, J., Ohno, T., Igarashi, H., Hara, T., Central nervous system vasculopathy associated with neonatal lupus (2002) Pediatr. Neurol., 26, pp. 68-70

PY - 2005

Y1 - 2005

N2 - Neonatal lupus erythematosus is an uncommon passive autoimmune disease in which there is a transplacental passage of anti-Ro/SSA and/or anti-La/SSB maternal autoantibodies. Common clinical manifestations include cardiac disease, notably congenital heart block, cutaneous lupus lesions, hematologic disorders, and hepatobiliary disease. During the past decade, however, it has become clear that central nervous disease may also be a manifestation of neonatal lupus. We report a male neonate with the disease who had focal seizures in addition to cutaneous lupus, anemia, and thrombocytopenia. Brain ultrasound revealed normal ventricular size without a midline shift or intracranial or intraventricular hemorrhage. A brain CT showed generalized low density involving the periventricular and deep white matter. A sleep EEG revealed rare spikes axial to the right parietal lobe. The neonate had a high titer of antinuclear antibodies (1:640) with a speckled pattern, anti-Ro/SSA and anti-La/SSB antibodies, but no anti-dsDNA antibodies. He was given anti-convulsant drugs with dramatic improvement of his symptoms. One month later, a sleep EEG was normal, and he had no further seizures.

AB - Neonatal lupus erythematosus is an uncommon passive autoimmune disease in which there is a transplacental passage of anti-Ro/SSA and/or anti-La/SSB maternal autoantibodies. Common clinical manifestations include cardiac disease, notably congenital heart block, cutaneous lupus lesions, hematologic disorders, and hepatobiliary disease. During the past decade, however, it has become clear that central nervous disease may also be a manifestation of neonatal lupus. We report a male neonate with the disease who had focal seizures in addition to cutaneous lupus, anemia, and thrombocytopenia. Brain ultrasound revealed normal ventricular size without a midline shift or intracranial or intraventricular hemorrhage. A brain CT showed generalized low density involving the periventricular and deep white matter. A sleep EEG revealed rare spikes axial to the right parietal lobe. The neonate had a high titer of antinuclear antibodies (1:640) with a speckled pattern, anti-Ro/SSA and anti-La/SSB antibodies, but no anti-dsDNA antibodies. He was given anti-convulsant drugs with dramatic improvement of his symptoms. One month later, a sleep EEG was normal, and he had no further seizures.

KW - anticonvulsive agent

KW - antinuclear antibody

KW - autoantibody

KW - La antibody

KW - maternal antibody

KW - phenobarbital

KW - phenytoin

KW - Ro antibody

KW - anemia

KW - antibody titer

KW - article

KW - autoimmune disease

KW - brain hemorrhage

KW - case report

KW - clinical feature

KW - computer assisted tomography

KW - congenital heart block

KW - drug response

KW - echoencephalography

KW - electroencephalography

KW - focal epilepsy

KW - hematologic disease

KW - hepatobiliary disease

KW - human

KW - laboratory test

KW - lupus erythematosus

KW - male

KW - newborn

KW - newborn disease

KW - parietal lobe

KW - placental transfer

KW - skin lupus erythematosus

KW - spike wave

KW - thrombocytopenia

KW - white matter

KW - Anemia

KW - Anticonvulsants

KW - Autoantigens

KW - Humans

KW - Infant, Newborn

KW - Lupus Erythematosus, Cutaneous

KW - Lupus Erythematosus, Systemic

KW - Male

KW - Phenytoin

KW - Ribonucleoproteins

KW - Seizures

KW - Thrombocytopenia

M3 - Article

VL - 23

SP - 61

EP - 64

JO - Asian Pacific Journal of Allergy and Immunology

JF - Asian Pacific Journal of Allergy and Immunology

SN - 0125-877X

IS - 1

ER -