Fluoxetine regulates cell growth inhibition of interferon-α

Yu Min Lin, Bu Chin Yu, Wen Tai Chiu, Hung Yu Sun, Yu Chieh Chien, Hui Chen Su, Shu Yang Yen, Hsin Wen Lai, Chyi Huey Bai, Kung Chia Young, Chiung Wen Tsao

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

Fluoxetine, a well-known anti-depression agent, may act as a chemosensitizer to assist and promote cancer therapy. However, how fluoxetine regulates cellular signaling to enhance cellular responses against tumor cell growth remains unclear. In the present study, addition of fluoxetine promoted growth inhibition of interferon-alpha (IFN-α) in human bladder carcinoma cells but not in normal uroepithelial cells through lessening the IFN-α-induced apoptosis but switching to cause G1 arrest, and maintaining the IFN-α- mediated reduction in G2/M phase. Activations and signal transducer and transactivator (STAT)-1 and peroxisome proliferator-activated receptor alpha (PPAR-α) were involved in this process. Chemical inhibitions of STAT-1 or PPAR-α partially rescued bladder carcinoma cells from IFN-α- mediated growth inhibition via blockades of G1 arrest, cyclin D1 reduction, p53 downregulation and p27 upregulation in the presence of fluoxetine. However, the functions of both proteins were not involved in the control of fluoxetine over apoptosis and maintained the declined G2/M phase of IFN-α. These results indicated that activation of PPAR-α and STAT-1 participated, at least in part, in growth inhibition of IFN-α in the presence of fluoxetine.
原文英語
頁(從 - 到)1746-1754
頁數9
期刊International Journal of Oncology
49
發行號4
DOIs
出版狀態已發佈 - 十月 1 2016

指紋

Fluoxetine
Interferon-alpha
Interferons
Peroxisome Proliferator-Activated Receptors
Trans-Activators
Growth
Transducers
G2 Phase
Cell Division
Urinary Bladder
Apoptosis
Carcinoma
PPAR alpha
Cyclin D1
Neoplasms
Up-Regulation
Down-Regulation
Proteins

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

引用此文

Lin, Y. M., Yu, B. C., Chiu, W. T., Sun, H. Y., Chien, Y. C., Su, H. C., ... Tsao, C. W. (2016). Fluoxetine regulates cell growth inhibition of interferon-α. International Journal of Oncology, 49(4), 1746-1754. https://doi.org/10.3892/ijo.2016.3650

Fluoxetine regulates cell growth inhibition of interferon-α. / Lin, Yu Min; Yu, Bu Chin; Chiu, Wen Tai; Sun, Hung Yu; Chien, Yu Chieh; Su, Hui Chen; Yen, Shu Yang; Lai, Hsin Wen; Bai, Chyi Huey; Young, Kung Chia; Tsao, Chiung Wen.

於: International Journal of Oncology, 卷 49, 編號 4, 01.10.2016, p. 1746-1754.

研究成果: 雜誌貢獻文章

Lin, YM, Yu, BC, Chiu, WT, Sun, HY, Chien, YC, Su, HC, Yen, SY, Lai, HW, Bai, CH, Young, KC & Tsao, CW 2016, 'Fluoxetine regulates cell growth inhibition of interferon-α', International Journal of Oncology, 卷 49, 編號 4, 頁 1746-1754. https://doi.org/10.3892/ijo.2016.3650
Lin YM, Yu BC, Chiu WT, Sun HY, Chien YC, Su HC 等. Fluoxetine regulates cell growth inhibition of interferon-α. International Journal of Oncology. 2016 10月 1;49(4):1746-1754. https://doi.org/10.3892/ijo.2016.3650
Lin, Yu Min ; Yu, Bu Chin ; Chiu, Wen Tai ; Sun, Hung Yu ; Chien, Yu Chieh ; Su, Hui Chen ; Yen, Shu Yang ; Lai, Hsin Wen ; Bai, Chyi Huey ; Young, Kung Chia ; Tsao, Chiung Wen. / Fluoxetine regulates cell growth inhibition of interferon-α. 於: International Journal of Oncology. 2016 ; 卷 49, 編號 4. 頁 1746-1754.
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