Fluoxetine regulates cell growth inhibition of interferon-α

Yu Min Lin, Bu Chin Yu, Wen Tai Chiu, Hung Yu Sun, Yu Chieh Chien, Hui Chen Su, Shu Yang Yen, Hsin Wen Lai, Chyi Huey Bai, Kung Chia Young, Chiung Wen Tsao

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)

摘要

Fluoxetine, a well-known anti-depression agent, may act as a chemosensitizer to assist and promote cancer therapy. However, how fluoxetine regulates cellular signaling to enhance cellular responses against tumor cell growth remains unclear. In the present study, addition of fluoxetine promoted growth inhibition of interferon-alpha (IFN-α) in human bladder carcinoma cells but not in normal uroepithelial cells through lessening the IFN-α-induced apoptosis but switching to cause G1 arrest, and maintaining the IFN-α- mediated reduction in G2/M phase. Activations and signal transducer and transactivator (STAT)-1 and peroxisome proliferator-activated receptor alpha (PPAR-α) were involved in this process. Chemical inhibitions of STAT-1 or PPAR-α partially rescued bladder carcinoma cells from IFN-α- mediated growth inhibition via blockades of G1 arrest, cyclin D1 reduction, p53 downregulation and p27 upregulation in the presence of fluoxetine. However, the functions of both proteins were not involved in the control of fluoxetine over apoptosis and maintained the declined G2/M phase of IFN-α. These results indicated that activation of PPAR-α and STAT-1 participated, at least in part, in growth inhibition of IFN-α in the presence of fluoxetine.
原文英語
頁(從 - 到)1746-1754
頁數9
期刊International Journal of Oncology
49
發行號4
DOIs
出版狀態已發佈 - 十月 1 2016

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

指紋 深入研究「Fluoxetine regulates cell growth inhibition of interferon-α」主題。共同形成了獨特的指紋。

  • 引用此

    Lin, Y. M., Yu, B. C., Chiu, W. T., Sun, H. Y., Chien, Y. C., Su, H. C., Yen, S. Y., Lai, H. W., Bai, C. H., Young, K. C., & Tsao, C. W. (2016). Fluoxetine regulates cell growth inhibition of interferon-α. International Journal of Oncology, 49(4), 1746-1754. https://doi.org/10.3892/ijo.2016.3650