First phase release coefficient of insulin in subjects with normal glucose tolerance on glucose infusion analyzed by computer simulation

Chien Ning Huang, Wen Chih Chou, Li Yun Lin, Chiung Chi Peng, Charng Cherng Chyau, Kuan Chou Chen, Robert Y. Peng

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

We report here a mathematical model using computer simulation to solve the phase fractionation coefficient (f) of instantaneous insulin release on glucose infusion. By extensive model testing with the cited parameters obtained from the literature, the values of the factor f were shown to lie in range of 0.93 ± 0.02 (mean ± 2S.D., n = 15), indicating that the high pulsatile bolus of glucose by i.v. infusion may trigger acute insulin release (AIR) corresponding to a fraction of more than 90% of the stored insulin release in the first phase from the secretory granules of pancreatic β cells. In addition, the value of the factor f was shown to be independent of both the glucose infusion method and the non-insulin-dependent uptake of glucose.

原文英語
頁(從 - 到)146-157
頁數12
期刊BioSystems
91
發行號1
DOIs
出版狀態已發佈 - 一月 2008
對外發佈

ASJC Scopus subject areas

  • 生態學、進化論、行為學與系統學
  • 生物技術
  • 藥物發現

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