Film-forming polymer-granulated excipients as the matrix materials for controlled release dosage forms

Tsuimin Tsai, Yu Ping San, Hsiu O. Ho, Jen Sen Wu, Ming Thau Sheu

研究成果: 雜誌貢獻文章同行評審

21 引文 斯高帕斯(Scopus)

摘要

Lactose and dibasic calcium phosphate (DCP) were granulated with various concentrations of film-forming polymers by a stepwise spraying method to prepare a directly compressible matrix excipient. The film-forming polymeric latex of Eudragit RS-30D, Eudragit RL-30D, and Surelease (ethylcellulose) were used in this study as the source of the granulating materials. Better flowability and compressibility were observed for all the granulated particles than the polymer-free granules. Most tablets prepared from the polymer-granulated particles exhibited satisfactory friability of less than 1% except for those prepared from lactose particles granulated with low concentrations of ethylcellulose and from plain lactose granules. Change in tensile strength and tablet thickness were in good agreement with the plasticity of the granulating polymer. Polymergranulated lactose and DCP provided for controlled release of captopril from matrix tablets. This investigation suggests that conventional excipients can be modified by a simple granulating procedure to provide better physical properties for being used as a matrix material.

原文英語
頁(從 - 到)289-299
頁數11
期刊Journal of Controlled Release
51
發行號2-3
DOIs
出版狀態已發佈 - 二月 12 1998

ASJC Scopus subject areas

  • 藥學科學

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