Fibronectin receptor structures in the VLA family of heterodimers

Yoshikazu Takada, Christina Huang, Martin E. Hemler

研究成果: 雜誌貢獻文章同行評審

130 引文 斯高帕斯(Scopus)

摘要

Multiple cell surface proteins of relative molecular mass 115,000-155,000 (Mr 115K-155K) have been implicated as receptors mediating adhesion to extracellular matrix proteins1-16. But the organization and relatedness of these peptides has remained unclear. In separate studies, the 'very late antigens' VLA-1 (Mr 210K/130K) and VLA-2 (Mr 160K/130K) were initially characterized as surface heterodimers appearing 2-4 weeks after in vitro stimulation of human T cells17-19. Three more VLA heterodimers have since been discovered, which, like VLA-1 and VLA-2 (refs 18,20,21), are each composed of unique α-subunits in association with a common 130K β subunit22. This paper shows that the common VLA β-subunit is equivalent to subunits found in structures with known fibronectin and laminin receptor activity9-12, and that VLA-3 and VLA-522 are similar or identical to these previously defined receptors for adhesion molecules. Antibody blocking studies confirmed that at least some of the widely distributed VLA proteins of previously unknown function are involved in cell adhesion to fibronectin and laminin. We suggest that the VLA family of receptors may provide cells with multiple independent substrate adhesion capabilities.

原文英語
頁(從 - 到)607-609
頁數3
期刊Nature
326
發行號6113
DOIs
出版狀態已發佈 - 1987

ASJC Scopus subject areas

  • General

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