Fibrin sealant: Scientific rationale, production methods, properties, and current clinical use

M. Radosevich, H. A. Goubran, T. Burnouf

研究成果: 雜誌貢獻回顧型文獻同行評審

293 引文 斯高帕斯(Scopus)

摘要

Fibrin sealant is a complex plasma-derived product which is increasingly used as a biodegradable tissue adhesive or sealant to stop or control bleeding or provide air and fluid tightness in many surgical situations. This review describes the historical development of current fibrin sealant preparations and the scientific rationale behind the alleged physiological benefits of its major plasma-derived components. A comparison in the extraction methods and viral reduction treatments applied to current commercial products and autologous preparations, and their respective advantages and limits, are discussed. Application devices used for surgical applications are described. A survey of the major clinical applications in various surgical areas is presented. Current issues in terms of viral safety, definition of optimal fibrin sealant composition, and regulatory concerns, especially to demonstrate clinical efficacy, are also included.
原文英語
頁(從 - 到)133-143
頁數11
期刊Vox Sanguinis
72
發行號3
出版狀態已發佈 - 四月 1997
對外發佈

ASJC Scopus subject areas

  • 血液學

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