Fibrin based drug delivery systems

R. I. Senderoff, M. T. Sheu, T. D. Sokoloski

研究成果: 雜誌貢獻文章同行評審

29 引文 斯高帕斯(Scopus)

摘要

Fibrinogen is the natural substrate for thrombin, the final proteolytic enzyme of the blood coagulation cascade. Following reaction with thrombin, fibrinogen is converted into fibrin monomers which then spontaneously polymerize into fibrin threads forming the fibrin matrix. This biochemical reaction between fibrinogen and thrombin has been used to produce natural, biodegradable, biocompatible systems for sustained drug delivery. Three potential delivery systems have been explored: 1) fibrin microparticles with drug entrapped are produced by an emulsion process, 2) reaction between fibrinogen adsorbed on suspended drug and thrombin in solution results in the formation of fibrin-coated drug particulates, and 3) fibrin sheets suitable as implants have been cast with drug entrapped. The drug release behavior of both small and large molecular weight substances from these systems was evaluated.

原文英語
頁(從 - 到)2-6
頁數5
期刊Journal of Parenteral Science and Technology
45
發行號1
出版狀態已發佈 - 1991
對外發佈

ASJC Scopus subject areas

  • 藥學科學

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