Fetal ascites and second trimester maternal hepatitis C virus infection

Pei Ying Ling, Shiuh Bin Fang, Wen Chien Liao, Yen Mong Lu, Hei Jen Jou

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5 引文 斯高帕斯(Scopus)


Objective: To present the first reported case of early second trimester maternal hepatitis C virus (HCV) associated with fetal ascites, which was treated with fetal paracentesis, and resulted in a successful outcome of a term liveborn infant with anti-HCV seropositivity. Case Report: A 26-year-old primigravida woman was diagnosed with acute HCV infection at 17 weeks of gestation. Ultrasound (US) at 23 weeks showed significant fetal ascites and echogenic bowel, and fetal viral infection was suspected. Maternal serum was positive for high HCV-RNA titers and cytomegalovirus (CMV) IgG. Amniocentesis, cordocentesis and therapeutic fetal paracentesis were performed at 23 weeks. Fetal karyotype was 46,XX. Cord blood showed anti-HCV positivity and HCV-RNA titer <10. Amniotic fluid was anti-HCV and CMV IgG positive. US at 27 weeks showed complete resolution of fetal ascites. A healthy 2,976 g female baby was delivered at 37 weeks, with anti-HCV seropositivity, high HCV-RNA titers, CMV IgG positive, IgM negative and normal liver function tests at the 1-month follow-up. Conclusion: Second trimester perinatal HCV infection with possible CMV coinfection associated with fetal ascites is a rare event. Fetal therapy resulting in a successful outcome has not been reported. Prompt fetal therapy with paracentesis in this case led to the delivery of a healthy term liveborn baby with anti-HCV seropositivity.
頁(從 - 到)260-263
期刊Taiwanese Journal of Obstetrics and Gynecology
出版狀態已發佈 - 9月 2006

ASJC Scopus subject areas

  • 婦產科


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