Feruloyl-l-arabinose attenuates migration, invasion and production of reactive oxygen species in H1299 lung cancer cells

Hsin Yu Fang, Hui Min Wang, Kuo Feng Chang, Huei Ting Hu, Lian Je Hwang, Tzu Fun Fu, Yin Chieh Lin, Wei Chiao Chang, Tsu Pei Chiu, Zhi Hong Wen, Yao Fong, Chien Chih Chiu, Bing Hung Chen

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

摘要

Ferulic acid (FA), a phenolic compound, is an abundant dietary antioxidant and exerts the mitogenic effect on cells. Recently, we isolated an active FA derivative, namely feruloyl-. l-arabinose (FAA), from coba husk. The aim of this study was to investigate the effects of FAA on the proliferation, migration and invasion of H1299 human lung cancer cells. Our results showed a strong antioxidant potential of FAA. Additionally, FAA inhibited the migration and invasion ability, while causing a significant accumulation of G2/M-population, of H1299 tumor cells in a dose-dependent manner, whereas no significant change on cell proliferation was observed. Results from the wound healing assay revealed that cell migration ability was markedly inhibited by FAA treatments. Similarly, results of gelatin zymography study showed that FAA treatments significantly decreased the activities of matrix metalloproteinase (MMP)-2 and MMP-9, suggesting that FAA-mediated inhibition on migration and invasion of lung cancer cells may be achieved by the down-regulation of the MMPs activities. Taken together, our present work provides a new insight into the novel inhibitory function of FAA on cell migration in H1299 cells, suggesting its promising role in the chemoprevention of lung cancer.

原文英語
頁(從 - 到)459-466
頁數8
期刊Food and Chemical Toxicology
58
DOIs
出版狀態已發佈 - 八月 2013

ASJC Scopus subject areas

  • Food Science
  • Toxicology

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