Feasibility of Two-Dimensional Radiation Dose Distribution Simulation Through Ultrasound Tracking of Respiratory Motion

Chia-Chun Kuo, Ho-Chiao Chuang, Chan-Yang Kuo, Lai-Lei Ting, Hsiao-Wei Yu, Yu-Peng Wu, Hsiao-Yu Hsu, Der-Chi Tien, Shiu-Chen Jeng, Jeng-Fong Chiou

研究成果: 雜誌貢獻文章

摘要

This study applied an ultrasound image tracking algorithm (UITA) for tracking respiration and developed a 2D dose distribution simulation program (DDSP) for simulating a dose distribution map. We evaluated the feasibility of a 2D respiratory motion simulation system combined with the UITA during radiotherapy for tracking respiration. The recorded respiration signals were input to the DDSP to generate a simulated dose distribution map and verify the effectiveness of the Gafchromic Film EBT3 (EBT3 film) as a measured dose distribution map (MDDM), to validate the DDSP. A radiation dose was delivered to EBT3 film and the film response was quantified using the isodose area rate (IAR), average dose rate within the field (ADFR), conformity index rate (CIR), and gamma passing rate. The tracking performance was evaluated by calculating the root mean squared error (RMSE). The calculated RMSEs were 1.67–5.34 and 0.42–2.53 mm in superior–inferior and right–left directions, respectively. The ADFR was 0.93–1.21 and the IARs at 20, 50, 70, and 80% were 0.87–1.29, 0.84–1.16, 0.79–1.61, and 0.48–6.64, respectively. The CIRs at 50, 70, and 80% were 0.87–1.23, 0.84–1.29, and 0.81–4.40, respectively. The human respiration patterns exhibited a 3%/3 mm gamma passing rate of 76.56–96.94%. This study successfully used an ultrasound imaging system to capture human respiration signals and transmit them to the DDSP for simulating radiation dose distributions, thus demonstrating the feasibility of the system.
原文英語
期刊Journal of Medical and Biological Engineering
DOIs
出版狀態已發佈 - 五月 4 2018

引用此文

Feasibility of Two-Dimensional Radiation Dose Distribution Simulation Through Ultrasound Tracking of Respiratory Motion. / Kuo, Chia-Chun; Chuang, Ho-Chiao; Kuo, Chan-Yang; Ting, Lai-Lei; Yu, Hsiao-Wei; Wu, Yu-Peng; Hsu, Hsiao-Yu; Tien, Der-Chi; Jeng, Shiu-Chen; Chiou, Jeng-Fong.

於: Journal of Medical and Biological Engineering, 04.05.2018.

研究成果: 雜誌貢獻文章

Kuo, Chia-Chun ; Chuang, Ho-Chiao ; Kuo, Chan-Yang ; Ting, Lai-Lei ; Yu, Hsiao-Wei ; Wu, Yu-Peng ; Hsu, Hsiao-Yu ; Tien, Der-Chi ; Jeng, Shiu-Chen ; Chiou, Jeng-Fong. / Feasibility of Two-Dimensional Radiation Dose Distribution Simulation Through Ultrasound Tracking of Respiratory Motion. 於: Journal of Medical and Biological Engineering. 2018.
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title = "Feasibility of Two-Dimensional Radiation Dose Distribution Simulation Through Ultrasound Tracking of Respiratory Motion",
abstract = "This study applied an ultrasound image tracking algorithm (UITA) for tracking respiration and developed a 2D dose distribution simulation program (DDSP) for simulating a dose distribution map. We evaluated the feasibility of a 2D respiratory motion simulation system combined with the UITA during radiotherapy for tracking respiration. The recorded respiration signals were input to the DDSP to generate a simulated dose distribution map and verify the effectiveness of the Gafchromic Film EBT3 (EBT3 film) as a measured dose distribution map (MDDM), to validate the DDSP. A radiation dose was delivered to EBT3 film and the film response was quantified using the isodose area rate (IAR), average dose rate within the field (ADFR), conformity index rate (CIR), and gamma passing rate. The tracking performance was evaluated by calculating the root mean squared error (RMSE). The calculated RMSEs were 1.67–5.34 and 0.42–2.53 mm in superior–inferior and right–left directions, respectively. The ADFR was 0.93–1.21 and the IARs at 20, 50, 70, and 80{\%} were 0.87–1.29, 0.84–1.16, 0.79–1.61, and 0.48–6.64, respectively. The CIRs at 50, 70, and 80{\%} were 0.87–1.23, 0.84–1.29, and 0.81–4.40, respectively. The human respiration patterns exhibited a 3{\%}/3 mm gamma passing rate of 76.56–96.94{\%}. This study successfully used an ultrasound imaging system to capture human respiration signals and transmit them to the DDSP for simulating radiation dose distributions, thus demonstrating the feasibility of the system.",
author = "Chia-Chun Kuo and Ho-Chiao Chuang and Chan-Yang Kuo and Lai-Lei Ting and Hsiao-Wei Yu and Yu-Peng Wu and Hsiao-Yu Hsu and Der-Chi Tien and Shiu-Chen Jeng and Jeng-Fong Chiou",
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doi = "10.1007/s40846-018-0420-z",
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T1 - Feasibility of Two-Dimensional Radiation Dose Distribution Simulation Through Ultrasound Tracking of Respiratory Motion

AU - Kuo, Chia-Chun

AU - Chuang, Ho-Chiao

AU - Kuo, Chan-Yang

AU - Ting, Lai-Lei

AU - Yu, Hsiao-Wei

AU - Wu, Yu-Peng

AU - Hsu, Hsiao-Yu

AU - Tien, Der-Chi

AU - Jeng, Shiu-Chen

AU - Chiou, Jeng-Fong

PY - 2018/5/4

Y1 - 2018/5/4

N2 - This study applied an ultrasound image tracking algorithm (UITA) for tracking respiration and developed a 2D dose distribution simulation program (DDSP) for simulating a dose distribution map. We evaluated the feasibility of a 2D respiratory motion simulation system combined with the UITA during radiotherapy for tracking respiration. The recorded respiration signals were input to the DDSP to generate a simulated dose distribution map and verify the effectiveness of the Gafchromic Film EBT3 (EBT3 film) as a measured dose distribution map (MDDM), to validate the DDSP. A radiation dose was delivered to EBT3 film and the film response was quantified using the isodose area rate (IAR), average dose rate within the field (ADFR), conformity index rate (CIR), and gamma passing rate. The tracking performance was evaluated by calculating the root mean squared error (RMSE). The calculated RMSEs were 1.67–5.34 and 0.42–2.53 mm in superior–inferior and right–left directions, respectively. The ADFR was 0.93–1.21 and the IARs at 20, 50, 70, and 80% were 0.87–1.29, 0.84–1.16, 0.79–1.61, and 0.48–6.64, respectively. The CIRs at 50, 70, and 80% were 0.87–1.23, 0.84–1.29, and 0.81–4.40, respectively. The human respiration patterns exhibited a 3%/3 mm gamma passing rate of 76.56–96.94%. This study successfully used an ultrasound imaging system to capture human respiration signals and transmit them to the DDSP for simulating radiation dose distributions, thus demonstrating the feasibility of the system.

AB - This study applied an ultrasound image tracking algorithm (UITA) for tracking respiration and developed a 2D dose distribution simulation program (DDSP) for simulating a dose distribution map. We evaluated the feasibility of a 2D respiratory motion simulation system combined with the UITA during radiotherapy for tracking respiration. The recorded respiration signals were input to the DDSP to generate a simulated dose distribution map and verify the effectiveness of the Gafchromic Film EBT3 (EBT3 film) as a measured dose distribution map (MDDM), to validate the DDSP. A radiation dose was delivered to EBT3 film and the film response was quantified using the isodose area rate (IAR), average dose rate within the field (ADFR), conformity index rate (CIR), and gamma passing rate. The tracking performance was evaluated by calculating the root mean squared error (RMSE). The calculated RMSEs were 1.67–5.34 and 0.42–2.53 mm in superior–inferior and right–left directions, respectively. The ADFR was 0.93–1.21 and the IARs at 20, 50, 70, and 80% were 0.87–1.29, 0.84–1.16, 0.79–1.61, and 0.48–6.64, respectively. The CIRs at 50, 70, and 80% were 0.87–1.23, 0.84–1.29, and 0.81–4.40, respectively. The human respiration patterns exhibited a 3%/3 mm gamma passing rate of 76.56–96.94%. This study successfully used an ultrasound imaging system to capture human respiration signals and transmit them to the DDSP for simulating radiation dose distributions, thus demonstrating the feasibility of the system.

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DO - 10.1007/s40846-018-0420-z

M3 - Article

JO - Journal of Medical and Biological Engineering

JF - Journal of Medical and Biological Engineering

SN - 1609-0985

ER -