Feasibility of bispectral index-guided propofol infusion for flexible bronchoscopy sedation: A randomized controlled trial

Yu Lun Lo, Ting Yu Lin, Yueh Fu Fang, Tsai Yu Wang, Hao Cheng Chen, Chun Liang Chou, Fu Tsai Chung, Chih Hsi Kuo, Po Hao Feng, Chien Ying Liu, Han Pin Kuo

研究成果: 雜誌貢獻文章同行評審

48 引文 斯高帕斯(Scopus)

摘要

Objectives: There are safety issues associated with propofol use for flexible bronchoscopy (FB). The bispectral index (BIS) correlates well with the level of consciousness. The aim of this study was to show that BIS-guided propofol infusion is safe and may provide better sedation, benefiting the patients and bronchoscopists. Methods: After administering alfentanil bolus, 500 patients were randomized to either propofol infusion titrated to a BIS level of 65-75 (study group) or incremental midazolam bolus based on clinical judgment to achieve moderate sedation. The primary endpoint was safety, while the secondary endpoints were recovery time, patient tolerance, and cooperation. Results: The proportion of patients with hypoxemia or hypotensive events were not different in the 2 groups (study vs. control groups: 39.9% vs. 35.7%, p = 0.340; 7.4% vs. 4.4%, p = 0.159, respectively). The mean lowest blood pressure was lower in the study group. Logistic regression revealed male gender, higher American Society of Anesthesiologists physical status, and electrocautery were associated with hypoxemia, whereas lower propofol dose for induction was associated with hypotension in the study group. The study group had better global tolerance (p
原文英語
文章編號e27769
期刊PLoS One
6
發行號11
DOIs
出版狀態已發佈 - 十一月 23 2011
對外發佈

ASJC Scopus subject areas

  • 農業與生物科學 (全部)
  • 生物化學、遺傳與分子生物學 (全部)
  • 醫藥 (全部)

指紋

深入研究「Feasibility of bispectral index-guided propofol infusion for flexible bronchoscopy sedation: A randomized controlled trial」主題。共同形成了獨特的指紋。

引用此