Familial occurrence of colon and uterine carcinoma and of lymphoproliferative malignancies. II. Chromosomal and immunologic abnormalities

Ivan P. Law, Ariel C. Hollinshead, Jacqueline Whang‐Peng, Jack H. Dean, Robert K. Oldham, Ronald B. Herberman, Marvin C. Rhode

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20 引文 斯高帕斯(Scopus)

摘要

Cytogenic and immunologic studies were performed on 20 members of a family who had an increased susceptibility to carcinomas of the colon, uterus and of lymphoproliferative malignancy. Chromosomal abnormalities such as small G and/or long submetacentric marker chromosome and other aberrations were observed in members who had cancer as well as some asymptomatic siblings. In addition, impairment of T cell function was noted in many of the members suggesting that defective cell‐mediated immunity, which also may be genetically determined, played an important role in the expression of this disease.
原文英語
頁(從 - 到)1229-1236
頁數8
期刊Cancer
39
發行號3
DOIs
出版狀態已發佈 - 一月 1 1977
對外發佈Yes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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