Factors correlated with number of metastatic lymph nodes in gastric cancer

King Han Shen, Chew Wun Wu, Su Shun Lo, Mao Chih Hsieh, Cheng Yuan Hsia, Shu Chiung Chiang, Wing Yiu Lui

研究成果: 雜誌貢獻文章

13 引文 (Scopus)

摘要

Objective: We had previously reported a reasonable categorization of the number of positive lymph nodes (LN: 0, 1-4, 5-8, and > 8) as a prognostic indicator. This study was an extension, to see which factors correlated with number of positive lymph nodes. Methods: A total of 533 patients with gastric adenocarcinoma, who underwent curative surgery between January 1988 and December 1995, were entered into this study. Patients were divided into four groups according to metastatic LN number (0, 1-4, 5-8, and > 8). Their survival and clinicopathological factors were analyzed. Results: A total of 16,457 LNs, with an average of 30.9 per specimen, were removed, of which 1686 (10.2%) showed metastases. The 5-yr cumulative survival rate decreased as the number of metastatic LNs increased, i.e., 91.3% for LN 0; 67.4% for LN 1-4; 37.2 for LN 5-8, and 14.1% for LN > 8. Multivariate analyses showed that depth of cancer invasion (odds ratio: 2.4), gross appearance (odds ratio: 1.9), size (odds ratio: 1.9), and location (odds ratio: 1.4) of tumor were four independent factors correlated with the number of metastatic LNs. Number of metastatic LNs increased with advanced Japanese nodal stage and UICC-TNM stage. Conclusions: Depth of tumor invasion, and gross appearance, size, and location of tumor were four pathological factors independently correlated with number of metastatic LNs in gastric cancer.
原文英語
頁(從 - 到)104-108
頁數5
期刊American Journal of Gastroenterology
94
發行號1
DOIs
出版狀態已發佈 - 一月 1999

指紋

Stomach Neoplasms
Lymph Nodes
Odds Ratio
Neoplasms
Stomach
Adenocarcinoma
Multivariate Analysis
Survival Rate
Neoplasm Metastasis
Survival

ASJC Scopus subject areas

  • Gastroenterology

引用此文

Factors correlated with number of metastatic lymph nodes in gastric cancer. / Shen, King Han; Wu, Chew Wun; Lo, Su Shun; Hsieh, Mao Chih; Hsia, Cheng Yuan; Chiang, Shu Chiung; Lui, Wing Yiu.

於: American Journal of Gastroenterology, 卷 94, 編號 1, 01.1999, p. 104-108.

研究成果: 雜誌貢獻文章

Shen, King Han ; Wu, Chew Wun ; Lo, Su Shun ; Hsieh, Mao Chih ; Hsia, Cheng Yuan ; Chiang, Shu Chiung ; Lui, Wing Yiu. / Factors correlated with number of metastatic lymph nodes in gastric cancer. 於: American Journal of Gastroenterology. 1999 ; 卷 94, 編號 1. 頁 104-108.
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title = "Factors correlated with number of metastatic lymph nodes in gastric cancer",
abstract = "Objective: We had previously reported a reasonable categorization of the number of positive lymph nodes (LN: 0, 1-4, 5-8, and > 8) as a prognostic indicator. This study was an extension, to see which factors correlated with number of positive lymph nodes. Methods: A total of 533 patients with gastric adenocarcinoma, who underwent curative surgery between January 1988 and December 1995, were entered into this study. Patients were divided into four groups according to metastatic LN number (0, 1-4, 5-8, and > 8). Their survival and clinicopathological factors were analyzed. Results: A total of 16,457 LNs, with an average of 30.9 per specimen, were removed, of which 1686 (10.2{\%}) showed metastases. The 5-yr cumulative survival rate decreased as the number of metastatic LNs increased, i.e., 91.3{\%} for LN 0; 67.4{\%} for LN 1-4; 37.2 for LN 5-8, and 14.1{\%} for LN > 8. Multivariate analyses showed that depth of cancer invasion (odds ratio: 2.4), gross appearance (odds ratio: 1.9), size (odds ratio: 1.9), and location (odds ratio: 1.4) of tumor were four independent factors correlated with the number of metastatic LNs. Number of metastatic LNs increased with advanced Japanese nodal stage and UICC-TNM stage. Conclusions: Depth of tumor invasion, and gross appearance, size, and location of tumor were four pathological factors independently correlated with number of metastatic LNs in gastric cancer.",
author = "Shen, {King Han} and Wu, {Chew Wun} and Lo, {Su Shun} and Hsieh, {Mao Chih} and Hsia, {Cheng Yuan} and Chiang, {Shu Chiung} and Lui, {Wing Yiu}",
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T1 - Factors correlated with number of metastatic lymph nodes in gastric cancer

AU - Shen, King Han

AU - Wu, Chew Wun

AU - Lo, Su Shun

AU - Hsieh, Mao Chih

AU - Hsia, Cheng Yuan

AU - Chiang, Shu Chiung

AU - Lui, Wing Yiu

PY - 1999/1

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N2 - Objective: We had previously reported a reasonable categorization of the number of positive lymph nodes (LN: 0, 1-4, 5-8, and > 8) as a prognostic indicator. This study was an extension, to see which factors correlated with number of positive lymph nodes. Methods: A total of 533 patients with gastric adenocarcinoma, who underwent curative surgery between January 1988 and December 1995, were entered into this study. Patients were divided into four groups according to metastatic LN number (0, 1-4, 5-8, and > 8). Their survival and clinicopathological factors were analyzed. Results: A total of 16,457 LNs, with an average of 30.9 per specimen, were removed, of which 1686 (10.2%) showed metastases. The 5-yr cumulative survival rate decreased as the number of metastatic LNs increased, i.e., 91.3% for LN 0; 67.4% for LN 1-4; 37.2 for LN 5-8, and 14.1% for LN > 8. Multivariate analyses showed that depth of cancer invasion (odds ratio: 2.4), gross appearance (odds ratio: 1.9), size (odds ratio: 1.9), and location (odds ratio: 1.4) of tumor were four independent factors correlated with the number of metastatic LNs. Number of metastatic LNs increased with advanced Japanese nodal stage and UICC-TNM stage. Conclusions: Depth of tumor invasion, and gross appearance, size, and location of tumor were four pathological factors independently correlated with number of metastatic LNs in gastric cancer.

AB - Objective: We had previously reported a reasonable categorization of the number of positive lymph nodes (LN: 0, 1-4, 5-8, and > 8) as a prognostic indicator. This study was an extension, to see which factors correlated with number of positive lymph nodes. Methods: A total of 533 patients with gastric adenocarcinoma, who underwent curative surgery between January 1988 and December 1995, were entered into this study. Patients were divided into four groups according to metastatic LN number (0, 1-4, 5-8, and > 8). Their survival and clinicopathological factors were analyzed. Results: A total of 16,457 LNs, with an average of 30.9 per specimen, were removed, of which 1686 (10.2%) showed metastases. The 5-yr cumulative survival rate decreased as the number of metastatic LNs increased, i.e., 91.3% for LN 0; 67.4% for LN 1-4; 37.2 for LN 5-8, and 14.1% for LN > 8. Multivariate analyses showed that depth of cancer invasion (odds ratio: 2.4), gross appearance (odds ratio: 1.9), size (odds ratio: 1.9), and location (odds ratio: 1.4) of tumor were four independent factors correlated with the number of metastatic LNs. Number of metastatic LNs increased with advanced Japanese nodal stage and UICC-TNM stage. Conclusions: Depth of tumor invasion, and gross appearance, size, and location of tumor were four pathological factors independently correlated with number of metastatic LNs in gastric cancer.

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