Factors Associated with Radiographic Spinal Involvement and Hip Involvement in Ankylosing Spondylitis

Hung An Chen, Chun Hsiung Chen, Hsien Tzung Liao, Yeong Jang Lin, Pei Chih Chen, Wei Sheng Chen, Chung Tei Chou

研究成果: 雜誌貢獻文章

39 引文 (Scopus)

摘要

Objectives: To determine the factors associated with radiographic spinal involvement and hip involvement in ankylosing spondylitis (AS) and assess the influence of the damage seen in the radiographs on functional outcome in patients with AS. Methods: We included 531 consecutive patients and recorded the clinical, laboratory, and radiographic data. Based on the spinal radiographs, patients were classified into 3 categories: (1) no spinal involvement; (2) spinal involvement without fusion; and (3) spinal involvement with fusion. Hip involvement was assessed by the Bath Ankylosing Spondylitis Radiology Hip Index and defined by a score of at least 2. Logistic regression analyses were used to investigate the factors associated with the radiographic spine and hip involvements. Results: Ninety-eight (18.5%) patients had radiographic evidence of spinal fusion and 48 (9.0%) had radiographic evidence of hip involvement. Patients who had longer disease duration, elevated C-reactive protein levels, advanced sacroiliitis, and radiographic hip involvement were significantly more likely to have spinal fusion (P <0.05). Elevated C-reactive protein levels and advanced sacroiliitis were also significantly associated with the presence of spinal involvement without fusion (P <0.05). Early disease onset and more radiographic severity in the spine and sacroiliac joints were the predictors of radiographic hip involvement (P <0.05). Patients with either spine or hip involvement had significantly higher Bath Ankylosing Spondylitis Functional Index scores (P <0.001). Conclusion: There is a relationship between radiographic sacroiliitis, spinal fusion, and hip involvement in patients with AS. Damage to the spine and hip seen radiographically can contribute to functional impairment.

原文英語
頁(從 - 到)552-558
頁數7
期刊Seminars in Arthritis and Rheumatism
40
發行號6
DOIs
出版狀態已發佈 - 六月 2011

指紋

Ankylosing Spondylitis
Hip
Sacroiliitis
Spinal Fusion
Spine
Baths
C-Reactive Protein
Sacroiliac Joint
Radiology
Logistic Models
Regression Analysis

ASJC Scopus subject areas

  • Rheumatology
  • Anesthesiology and Pain Medicine

引用此文

Factors Associated with Radiographic Spinal Involvement and Hip Involvement in Ankylosing Spondylitis. / Chen, Hung An; Chen, Chun Hsiung; Liao, Hsien Tzung; Lin, Yeong Jang; Chen, Pei Chih; Chen, Wei Sheng; Chou, Chung Tei.

於: Seminars in Arthritis and Rheumatism, 卷 40, 編號 6, 06.2011, p. 552-558.

研究成果: 雜誌貢獻文章

Chen, Hung An ; Chen, Chun Hsiung ; Liao, Hsien Tzung ; Lin, Yeong Jang ; Chen, Pei Chih ; Chen, Wei Sheng ; Chou, Chung Tei. / Factors Associated with Radiographic Spinal Involvement and Hip Involvement in Ankylosing Spondylitis. 於: Seminars in Arthritis and Rheumatism. 2011 ; 卷 40, 編號 6. 頁 552-558.
@article{191b749f14d2482e8e9b476ffb021d46,
title = "Factors Associated with Radiographic Spinal Involvement and Hip Involvement in Ankylosing Spondylitis",
abstract = "Objectives: To determine the factors associated with radiographic spinal involvement and hip involvement in ankylosing spondylitis (AS) and assess the influence of the damage seen in the radiographs on functional outcome in patients with AS. Methods: We included 531 consecutive patients and recorded the clinical, laboratory, and radiographic data. Based on the spinal radiographs, patients were classified into 3 categories: (1) no spinal involvement; (2) spinal involvement without fusion; and (3) spinal involvement with fusion. Hip involvement was assessed by the Bath Ankylosing Spondylitis Radiology Hip Index and defined by a score of at least 2. Logistic regression analyses were used to investigate the factors associated with the radiographic spine and hip involvements. Results: Ninety-eight (18.5{\%}) patients had radiographic evidence of spinal fusion and 48 (9.0{\%}) had radiographic evidence of hip involvement. Patients who had longer disease duration, elevated C-reactive protein levels, advanced sacroiliitis, and radiographic hip involvement were significantly more likely to have spinal fusion (P <0.05). Elevated C-reactive protein levels and advanced sacroiliitis were also significantly associated with the presence of spinal involvement without fusion (P <0.05). Early disease onset and more radiographic severity in the spine and sacroiliac joints were the predictors of radiographic hip involvement (P <0.05). Patients with either spine or hip involvement had significantly higher Bath Ankylosing Spondylitis Functional Index scores (P <0.001). Conclusion: There is a relationship between radiographic sacroiliitis, spinal fusion, and hip involvement in patients with AS. Damage to the spine and hip seen radiographically can contribute to functional impairment.",
keywords = "Ankylosing spondylitis, Hip involvement, Radiography, Spinal fusion",
author = "Chen, {Hung An} and Chen, {Chun Hsiung} and Liao, {Hsien Tzung} and Lin, {Yeong Jang} and Chen, {Pei Chih} and Chen, {Wei Sheng} and Chou, {Chung Tei}",
year = "2011",
month = "6",
doi = "10.1016/j.semarthrit.2010.07.008",
language = "English",
volume = "40",
pages = "552--558",
journal = "Seminars in Arthritis and Rheumatism",
issn = "0049-0172",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Factors Associated with Radiographic Spinal Involvement and Hip Involvement in Ankylosing Spondylitis

AU - Chen, Hung An

AU - Chen, Chun Hsiung

AU - Liao, Hsien Tzung

AU - Lin, Yeong Jang

AU - Chen, Pei Chih

AU - Chen, Wei Sheng

AU - Chou, Chung Tei

PY - 2011/6

Y1 - 2011/6

N2 - Objectives: To determine the factors associated with radiographic spinal involvement and hip involvement in ankylosing spondylitis (AS) and assess the influence of the damage seen in the radiographs on functional outcome in patients with AS. Methods: We included 531 consecutive patients and recorded the clinical, laboratory, and radiographic data. Based on the spinal radiographs, patients were classified into 3 categories: (1) no spinal involvement; (2) spinal involvement without fusion; and (3) spinal involvement with fusion. Hip involvement was assessed by the Bath Ankylosing Spondylitis Radiology Hip Index and defined by a score of at least 2. Logistic regression analyses were used to investigate the factors associated with the radiographic spine and hip involvements. Results: Ninety-eight (18.5%) patients had radiographic evidence of spinal fusion and 48 (9.0%) had radiographic evidence of hip involvement. Patients who had longer disease duration, elevated C-reactive protein levels, advanced sacroiliitis, and radiographic hip involvement were significantly more likely to have spinal fusion (P <0.05). Elevated C-reactive protein levels and advanced sacroiliitis were also significantly associated with the presence of spinal involvement without fusion (P <0.05). Early disease onset and more radiographic severity in the spine and sacroiliac joints were the predictors of radiographic hip involvement (P <0.05). Patients with either spine or hip involvement had significantly higher Bath Ankylosing Spondylitis Functional Index scores (P <0.001). Conclusion: There is a relationship between radiographic sacroiliitis, spinal fusion, and hip involvement in patients with AS. Damage to the spine and hip seen radiographically can contribute to functional impairment.

AB - Objectives: To determine the factors associated with radiographic spinal involvement and hip involvement in ankylosing spondylitis (AS) and assess the influence of the damage seen in the radiographs on functional outcome in patients with AS. Methods: We included 531 consecutive patients and recorded the clinical, laboratory, and radiographic data. Based on the spinal radiographs, patients were classified into 3 categories: (1) no spinal involvement; (2) spinal involvement without fusion; and (3) spinal involvement with fusion. Hip involvement was assessed by the Bath Ankylosing Spondylitis Radiology Hip Index and defined by a score of at least 2. Logistic regression analyses were used to investigate the factors associated with the radiographic spine and hip involvements. Results: Ninety-eight (18.5%) patients had radiographic evidence of spinal fusion and 48 (9.0%) had radiographic evidence of hip involvement. Patients who had longer disease duration, elevated C-reactive protein levels, advanced sacroiliitis, and radiographic hip involvement were significantly more likely to have spinal fusion (P <0.05). Elevated C-reactive protein levels and advanced sacroiliitis were also significantly associated with the presence of spinal involvement without fusion (P <0.05). Early disease onset and more radiographic severity in the spine and sacroiliac joints were the predictors of radiographic hip involvement (P <0.05). Patients with either spine or hip involvement had significantly higher Bath Ankylosing Spondylitis Functional Index scores (P <0.001). Conclusion: There is a relationship between radiographic sacroiliitis, spinal fusion, and hip involvement in patients with AS. Damage to the spine and hip seen radiographically can contribute to functional impairment.

KW - Ankylosing spondylitis

KW - Hip involvement

KW - Radiography

KW - Spinal fusion

UR - http://www.scopus.com/inward/record.url?scp=79955976733&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955976733&partnerID=8YFLogxK

U2 - 10.1016/j.semarthrit.2010.07.008

DO - 10.1016/j.semarthrit.2010.07.008

M3 - Article

C2 - 20870274

AN - SCOPUS:79955976733

VL - 40

SP - 552

EP - 558

JO - Seminars in Arthritis and Rheumatism

JF - Seminars in Arthritis and Rheumatism

SN - 0049-0172

IS - 6

ER -