Factors Associated with Antidepressant Dosing in Asia: Findings from the Research on Asian Psychotropic Prescription Study

Kamini Rajaratnam, Yu Tao Xiang, Adarsh Tripathi, Helen Fung Kum Chiu, Tian Mei Si, Kok Yoon Chee, Ajit Avasthi, Sandeep Grover, Mian Yoon Chong, Hironori Kuga, Shigenobu Kanba, Yan Ling He, Min Soo Lee, Shu Yu Yang, Pichet Udomratn, Roy Abraham Kallivayalil, Andi J. Tanra, Margarita Maramis, Winston Wu Dien Shen, Norman SartoriusEe Heok Kua, Chay Hoon Tan, Rathi Mahendran, Naotaka Shinfuku, Min Yi Sum, Ross J. Baldessarini, Kang Sim

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6 引文 斯高帕斯(Scopus)

摘要

In this study, we sought to examine factors associated with dosing of antidepressants (ADs) in Asia. Based on reported data and clinical experience, we hypothesized that doses of ADs would be associated with demographic and clinical factors and would increase over time. This cross-sectional, pharmacoepidemiological study analyzed data collected within the Research Study on Asian Psychotropic Prescription Pattern for Antidepressants from 4164 participants in 10 Asian countries, using univariate and multivariate methods. The AD doses varied by twofold among countries (highest in PR China and RO Korea, lowest in Singapore and Indonesia), and averaged 124 (120-129) mg/d imipramine-equivalents. Average daily doses increased by 12% between 2004 and 2013. Doses were significantly higher among hospitalized patients and ranked by diagnosis: major depression > anxiety disorders > bipolar disorder, but were not associated with private/public or psychiatric/general-medical settings, nor with age, sex, or cotreatment with a mood stabilizer. In multivariate modeling, AD-dose remained significantly associated with major depressive disorder and being hospitalized. Doses of ADs have increased somewhat in Asia and were higher when used for major depression or anxiety disorders than for bipolar depression and for hospitalized psychiatric patients.

原文英語
頁(從 - 到)716-719
頁數4
期刊Journal of Clinical Psychopharmacology
36
發行號6
DOIs
出版狀態已發佈 - 十二月 1 2016

ASJC Scopus subject areas

  • 精神病學和心理健康
  • 藥學(醫學)

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