Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates

Wei Feng, Mavurapu Satyanarayana, Yuan chin Tsai, Angela A. Liu, Leroy F. Liu, Edmond J. LaVoie

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

摘要

Several new TOP1-targeting agents were prepared using as intermediates the N,N,N-trimethyl quaternary ammonium salts of either ARC-111 or its 12-aza analog (ARC-31), 3 and 4, respectively. Direct displacement of the quaternary ammonium group with water, imidazole, alkylethylenediamines, or polyhydroxylated alkylamines provides a convenient means for furthering the structure-activity relationships associated with these non-camptothecin TOP1-targeting agents.
原文英語
頁(從 - 到)3570-3572
頁數3
期刊Bioorganic and Medicinal Chemistry Letters
18
發行號12
DOIs
出版狀態已發佈 - 六月 15 2008
對外發佈Yes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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