TY - GEN
T1 - Fabrication of surface enhanced raman scattering (SERS)-active substrates by using dip-pen nanolithography
AU - Lee, Fei-Peng
AU - Chao, K.
AU - Hsieh, K. H.
AU - Ou, Keng-Liang
PY - 2013
Y1 - 2013
N2 - In this study, we propose an effective strategy to prepare a stable surface enhanced Raman scattering (SERS)-active substrate by using dip-pen nanolithography (DPN) with top-down wet chemical etching. This method was made by DPN to pattern arrays, 16- mercaplohexadecaoic acid (MHA) on Au/Cr/Si substrates and then ferri/ferrocyanide etching was adopted to remove the exposed gold. It is found that a nanostructure with φ 300 nm gold dots and the distance between dot and dot is 400 nm can be obtained on the surface of substrates after etching. These nanostructure gold dots can enhance local electromagnetic fields, inducing enhancement of analytes' Raman signal. This process supplies the effective and stable SERS-active substrate which can be used as biomedical applications, such as protein chip, and microorganisms' discrimination chip.
AB - In this study, we propose an effective strategy to prepare a stable surface enhanced Raman scattering (SERS)-active substrate by using dip-pen nanolithography (DPN) with top-down wet chemical etching. This method was made by DPN to pattern arrays, 16- mercaplohexadecaoic acid (MHA) on Au/Cr/Si substrates and then ferri/ferrocyanide etching was adopted to remove the exposed gold. It is found that a nanostructure with φ 300 nm gold dots and the distance between dot and dot is 400 nm can be obtained on the surface of substrates after etching. These nanostructure gold dots can enhance local electromagnetic fields, inducing enhancement of analytes' Raman signal. This process supplies the effective and stable SERS-active substrate which can be used as biomedical applications, such as protein chip, and microorganisms' discrimination chip.
UR - http://www.scopus.com/inward/record.url?scp=84885771825&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885771825&partnerID=8YFLogxK
U2 - 10.1149/05012.0301ecst
DO - 10.1149/05012.0301ecst
M3 - Conference contribution
AN - SCOPUS:84885771825
SN - 9781607683605
T3 - ECS Transactions
SP - 301
EP - 305
BT - Chemical Sensors 10 -and- MEMS/NEMS 10
PB - Electrochemical Society Inc.
T2 - Symposia on Chemical Sensors 10 - Chemical and Biological Sensors and Analytical Systems and Microfabricated and Nanofabricated Systems for MEMS/NEMS 10 - 222nd ECS Meeting/PRiME 2012
Y2 - 7 October 2012 through 12 October 2012
ER -