The aim of this study was to incorporate nanoscale Fe3O4 particles into a poly-L-lactide (PLLA) matrix to fabricate a magnetic and biodegradable composite. The physical and osteogenic functions of this material were tested. Injection molding was used to fabricate four nano-Fe3O4/PLLA composites with Fe3O4 mix ratios of 0%, 20%, 30%, and 40% (w/w). X-ray diffraction and hysteresis loop tests were performed to evaluate the physical properties of the nano-Fe3O4/PLLA composites. Tensile strength tests showed that the progressive addition of nano-Fe3O4 particles to the PLLA matrix results in higher elastic modulus and lower tensile strength. Images from scanning electron microscopy demonstrated that osteoblasts cultured on the 20% nano-Fe3O4/PLLA surface exhibited abundant filaments, which are a morphologic characteristic of osteoblastic differentiation. These results suggest that the 20% nano-Fe3O4/PLLA composite used in this study has the potential for future tissue engineering applications.
ASJC Scopus subject areas
- Polymers and Plastics
- Materials Chemistry
- Ceramics and Composites
Pan, Y. H., Wang, H. T., Wu, T. L., Fan, K. H., Huang, H. M., & Chang, W. J. (認可的出版社/出版中). Fabrication of Fe3O4/PLLA composites for use in bone tissue engineering. Polymer Composites. https://doi.org/10.1002/pc.23890