Extensive homology exists between Marek disease herpesvirus and its vaccine virus, herpesvirus of turkeys

C. P. Gibbs, K. Nazerian, L. F. Velicer, H. J. Kung

研究成果: 雜誌貢獻文章

27 引文 (Scopus)

摘要

Marek disease is a lymphomatous disease of chickens caused by infection of a herpesvirus, Marek disease virus (MDV). Marek disease is the only neoplastic disease for which a successful vaccine has been developed. The vaccine virus, herpesvirus of turkeys (HVT), is non-oncogenic in chickens. Despite the strong antigenic relationship between these viruses, previous studies showed that the two viral DNAs share little or no homology. Using less stringent hybridization conditions and methods that greatly improve the reassociation kinetics, we have reexamined the sequence homology between MDV and HVT DNA. We report here that HVT and MDV are far more closely related than previously reported. The homology between these two viral DNAs ranges between 70% and 95% of the respective genomes. Under the low stringency conditions used, MDV DNA fails to cross-hybridize with DNA from feline rhinotracheitis virus, an antigenically unrelated herpesvirus with a G-C content identical to that of MDV and HVT.
原文英語
頁(從 - 到)3365-3369
頁數5
期刊Proceedings of the National Academy of Sciences of the United States of America
81
發行號11 I
出版狀態已發佈 - 一月 1 1984
對外發佈Yes

指紋

Herpesvirus Vaccines
Marek Disease Vaccines
Meleagrid Herpesvirus 1
Marek Disease
Viruses
Viral DNA
Chickens
Herpesviridae Infections
DNA Viruses
Herpesviridae
DNA
Felidae
Base Composition
Sequence Homology
Vaccines
Genome

ASJC Scopus subject areas

  • General

引用此文

Extensive homology exists between Marek disease herpesvirus and its vaccine virus, herpesvirus of turkeys. / Gibbs, C. P.; Nazerian, K.; Velicer, L. F.; Kung, H. J.

於: Proceedings of the National Academy of Sciences of the United States of America, 卷 81, 編號 11 I, 01.01.1984, p. 3365-3369.

研究成果: 雜誌貢獻文章

@article{270e107b14ea4081a22a459430111682,
title = "Extensive homology exists between Marek disease herpesvirus and its vaccine virus, herpesvirus of turkeys",
abstract = "Marek disease is a lymphomatous disease of chickens caused by infection of a herpesvirus, Marek disease virus (MDV). Marek disease is the only neoplastic disease for which a successful vaccine has been developed. The vaccine virus, herpesvirus of turkeys (HVT), is non-oncogenic in chickens. Despite the strong antigenic relationship between these viruses, previous studies showed that the two viral DNAs share little or no homology. Using less stringent hybridization conditions and methods that greatly improve the reassociation kinetics, we have reexamined the sequence homology between MDV and HVT DNA. We report here that HVT and MDV are far more closely related than previously reported. The homology between these two viral DNAs ranges between 70{\%} and 95{\%} of the respective genomes. Under the low stringency conditions used, MDV DNA fails to cross-hybridize with DNA from feline rhinotracheitis virus, an antigenically unrelated herpesvirus with a G-C content identical to that of MDV and HVT.",
author = "Gibbs, {C. P.} and K. Nazerian and Velicer, {L. F.} and Kung, {H. J.}",
year = "1984",
month = "1",
day = "1",
language = "English",
volume = "81",
pages = "3365--3369",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "11 I",

}

TY - JOUR

T1 - Extensive homology exists between Marek disease herpesvirus and its vaccine virus, herpesvirus of turkeys

AU - Gibbs, C. P.

AU - Nazerian, K.

AU - Velicer, L. F.

AU - Kung, H. J.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - Marek disease is a lymphomatous disease of chickens caused by infection of a herpesvirus, Marek disease virus (MDV). Marek disease is the only neoplastic disease for which a successful vaccine has been developed. The vaccine virus, herpesvirus of turkeys (HVT), is non-oncogenic in chickens. Despite the strong antigenic relationship between these viruses, previous studies showed that the two viral DNAs share little or no homology. Using less stringent hybridization conditions and methods that greatly improve the reassociation kinetics, we have reexamined the sequence homology between MDV and HVT DNA. We report here that HVT and MDV are far more closely related than previously reported. The homology between these two viral DNAs ranges between 70% and 95% of the respective genomes. Under the low stringency conditions used, MDV DNA fails to cross-hybridize with DNA from feline rhinotracheitis virus, an antigenically unrelated herpesvirus with a G-C content identical to that of MDV and HVT.

AB - Marek disease is a lymphomatous disease of chickens caused by infection of a herpesvirus, Marek disease virus (MDV). Marek disease is the only neoplastic disease for which a successful vaccine has been developed. The vaccine virus, herpesvirus of turkeys (HVT), is non-oncogenic in chickens. Despite the strong antigenic relationship between these viruses, previous studies showed that the two viral DNAs share little or no homology. Using less stringent hybridization conditions and methods that greatly improve the reassociation kinetics, we have reexamined the sequence homology between MDV and HVT DNA. We report here that HVT and MDV are far more closely related than previously reported. The homology between these two viral DNAs ranges between 70% and 95% of the respective genomes. Under the low stringency conditions used, MDV DNA fails to cross-hybridize with DNA from feline rhinotracheitis virus, an antigenically unrelated herpesvirus with a G-C content identical to that of MDV and HVT.

UR - http://www.scopus.com/inward/record.url?scp=0021261022&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021261022&partnerID=8YFLogxK

M3 - Article

C2 - 6328512

AN - SCOPUS:0021261022

VL - 81

SP - 3365

EP - 3369

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 11 I

ER -