Expression of the interleukin-2 receptor α (CD25) is selectively decreased on decidual CD4 + and CD8 + T lymphocytes in normal pregnancies

Kunag Han Chao, Ming Yih Wu, Jehn Hsiahn Yang, Shee Uan Chen, Yu Shih Yang, Hong Nerng Ho

研究成果: 雜誌貢獻文章同行評審

37 引文 斯高帕斯(Scopus)

摘要

In a previous study, we demonstrated that the proportion of activated T cells (CD69 +CD3 + and HLA-DR +CD3 +) is higher in the endometrium and decidua after the luteal phase and throughout early pregnancy compared with in the peripheral blood. However, there was no difference in the proportion of CD25 +CD3 + lymphocytes between the endometrium and peripheral blood. In this study, we further verify that the levels of CD25 on CD4 + and CD8 + T lymphocytes are not increased in normal pregnancy, although the levels of CD69 and HLA-DR are markedly increased. We also elucidate that the amounts of all three activation molecules on local T lymphocytes are down-regulated in pregnancy compared with that during the luteal phase. Nevertheless, these decreases are significantly lessened in anembryonic pregnancies with both normal and abnormal karyotyping. However, in peripheral blood, the down-regulation of activation molecules levels in pregnancy is only demonstrated on CD4 + cells and for HLA-DR on CD8 + cells. Furthermore, dual activation marker analysis demonstrated that the expression of CD25 appears to be dissociated from CD69 and HLA-DR on the same decidual lymphocytes. Because IL-2Rα plays a pivotal role in the development and propagation of functional T cells, its depressed expression may result in maternal tolerance of the fetal allograft.
原文英語
頁(從 - 到)667-673
頁數7
期刊Molecular Human Reproduction
8
發行號7
出版狀態已發佈 - 7月 22 2002
對外發佈

ASJC Scopus subject areas

  • 生殖醫學
  • 胚胎學
  • 分子生物學
  • 遺傳學
  • 婦產科
  • 發展生物學
  • 細胞生物學

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