Expression of mutant nuclea β-catenin correlates with non-invasive hepatolocellular carcinoma, absence of portal vein spread, and good prognosis

Tsui Lien Mao, Jan Show Chu, Yung Ming Jeng, Po Lin Lai, Hey Chi Hsu

研究成果: 雜誌貢獻文章同行評審

100 引文 斯高帕斯(Scopus)

摘要

β-catenin has functions both in the cadherin-mediated cell adhesion system and in the signalling pathway that mediates dorsal axis patterning in the embryo; it has been shown to be aberrantly expressed or mutated in diverse types of human tumour, but the biological significance of this remains to be clarified. To elucidate the clinical implications of aberrant β-catenin expression and the potential differences between mutant and wild-type β-catenin protein expression in hepatocellular carcinoma (HCC), the protein expression was analysed by immunohistochemical staining, supplemented by the analysis of gene mutation. Among 372 unifocal primary HCCs, β-catenin was detected in the tumour cell membrane alone in 272 tumours (group A) and also in the nuclei in 100 (group B). In group A, 148 tumours had decreased β-catenin expression, but the reduction did not correlate with invasion or prognosis. When compared with group A, however, group B had significantly lower frequencies of hepatitis B surface antigen carrier (p=0.015), and α-fetoprotein elevation (p=0.0003), but more often had non-invasive HCC (p

原文英語
頁(從 - 到)95-101
頁數7
期刊Journal of Pathology
193
發行號1
DOIs
出版狀態已發佈 - 2001
對外發佈

ASJC Scopus subject areas

  • 病理學與法醫學

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