Expression of Epstein-Barr virus latent membrane protein 1 and B-cell leukemia-lymphoma 2 gene in nasopharyngeal carcinoma tissues

John Jenn Yenn Lu, Chi Long Chen, Tsuey Ying Hsu, Jen Yang Chen, Ih Jen Su, Winston C Y Yu, Czau Siung Yang

研究成果: 雜誌貢獻文章同行評審

9 引文 斯高帕斯(Scopus)

摘要

Co-expression of B-cell leukemia-lymphoma 2 gene (Bcl-2) and Epstein-Barr virus latent membrane protein 1 (LMP-1) in nasopharyngeal carcinoma tissues were tested using immunohistochemical methods. Results showed that there were 32% (14/44) and 68% (30/44) LMP-1 and Bcl-2-positive cases, respectively. Among the LMP-1-positive tissues, 8 (57%) of 14 specimens were also Bcl-2-positive. The level of LMP-1 and Bcl-2 expression was associated with the clinical stages of nasopharyngeal carcinoma. Furthermore, when LMP-1- and Bcl-2-positive cases were combined, the highest positive score was found in clinical stage II as well as in the early stage (stages I and II) of nasopharyngeal carcinoma. While further studies with more cases are needed, this study suggests that co-expression of Bcl-2 and LMP-1 may be involved in the process of nasopharyngeal carcinoma aggravation.

原文英語
頁(從 - 到)136-140
頁數5
期刊Journal of Microbiology, Immunology and Infection
35
發行號2
出版狀態已發佈 - 2002
對外發佈

ASJC Scopus subject areas

  • 免疫學與微生物學 (全部)
  • 免疫學和過敏
  • 微生物學(醫學)

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