Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: A multicentre immunohistochemical study in the Asia-Pacific region

T. C. Putti, K. F. To, H. C. Hsu, A. T C Chan, G. M. Lai, G. Tse, Y. S. Lee, J. Whang-Peng, M. Millward, L. Lin, X. Lin, C. S. Lee

研究成果: 雜誌貢獻文章

61 引文 (Scopus)

摘要

Aims: With ongoing efforts to target the epidermal growth factor receptor (EGFR)-mediated tumour growth in the treatment of selected human malignancies, there is a need to determine the expression levels of EGFR and to evaluate its prognostic value in various malignancies in the Asia-Pacific region. Methods and results: A total of 172 patients with head and neck squamous cell carcinomas from Australia, Hong Kong, Singapore, and Taiwan were selected for EGFR detection. Immunohistochemical staining was performed to evaluate EGFR expression. EGFR expression was present in 88.4% (152/172) of all cases tested. Specifically, EGFR expression was found in 91.3% (42/46), 84.6% (22/26), 84.1% (37/44), 96.0% (24/25), and 87.1% (27/31) cases of head and neck squamous cell carcinomas from the oral cavity, oropharynx, nasopharynx, hypopharynx, and larynx, respectively. The results demonstrate a stronger EGFR expression in T4 tumours (P = 0.017) and later clinical stages (P = 0.016). No significant correlation was seen with risk factors, primary tumour site and ethnicity. Conclusions: The majority of head and neck squamous cell carcinomas express EGFR, indicating the importance of studying the efficacy of anti-cancer therapy through this pathway. The results also show similar rates of receptor expression in head and neck squamous cell carcinoma patients from our region compared with other parts of the world.
原文英語
頁(從 - 到)144-151
頁數8
期刊Histopathology
41
發行號2
DOIs
出版狀態已發佈 - 2002
對外發佈Yes

指紋

Head and Neck Neoplasms
Epidermal Growth Factor Receptor
Multicenter Studies
Neoplasms
Hypopharynx
Oropharynx
Nasopharynx
Singapore
Hong Kong
Larynx
Taiwan
Mouth
Staining and Labeling
Carcinoma, squamous cell of head and neck
Therapeutics
Growth

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

引用此文

Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression : A multicentre immunohistochemical study in the Asia-Pacific region. / Putti, T. C.; To, K. F.; Hsu, H. C.; Chan, A. T C; Lai, G. M.; Tse, G.; Lee, Y. S.; Whang-Peng, J.; Millward, M.; Lin, L.; Lin, X.; Lee, C. S.

於: Histopathology, 卷 41, 編號 2, 2002, p. 144-151.

研究成果: 雜誌貢獻文章

Putti, T. C. ; To, K. F. ; Hsu, H. C. ; Chan, A. T C ; Lai, G. M. ; Tse, G. ; Lee, Y. S. ; Whang-Peng, J. ; Millward, M. ; Lin, L. ; Lin, X. ; Lee, C. S. / Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression : A multicentre immunohistochemical study in the Asia-Pacific region. 於: Histopathology. 2002 ; 卷 41, 編號 2. 頁 144-151.
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abstract = "Aims: With ongoing efforts to target the epidermal growth factor receptor (EGFR)-mediated tumour growth in the treatment of selected human malignancies, there is a need to determine the expression levels of EGFR and to evaluate its prognostic value in various malignancies in the Asia-Pacific region. Methods and results: A total of 172 patients with head and neck squamous cell carcinomas from Australia, Hong Kong, Singapore, and Taiwan were selected for EGFR detection. Immunohistochemical staining was performed to evaluate EGFR expression. EGFR expression was present in 88.4{\%} (152/172) of all cases tested. Specifically, EGFR expression was found in 91.3{\%} (42/46), 84.6{\%} (22/26), 84.1{\%} (37/44), 96.0{\%} (24/25), and 87.1{\%} (27/31) cases of head and neck squamous cell carcinomas from the oral cavity, oropharynx, nasopharynx, hypopharynx, and larynx, respectively. The results demonstrate a stronger EGFR expression in T4 tumours (P = 0.017) and later clinical stages (P = 0.016). No significant correlation was seen with risk factors, primary tumour site and ethnicity. Conclusions: The majority of head and neck squamous cell carcinomas express EGFR, indicating the importance of studying the efficacy of anti-cancer therapy through this pathway. The results also show similar rates of receptor expression in head and neck squamous cell carcinoma patients from our region compared with other parts of the world.",
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T2 - A multicentre immunohistochemical study in the Asia-Pacific region

AU - Putti, T. C.

AU - To, K. F.

AU - Hsu, H. C.

AU - Chan, A. T C

AU - Lai, G. M.

AU - Tse, G.

AU - Lee, Y. S.

AU - Whang-Peng, J.

AU - Millward, M.

AU - Lin, L.

AU - Lin, X.

AU - Lee, C. S.

PY - 2002

Y1 - 2002

N2 - Aims: With ongoing efforts to target the epidermal growth factor receptor (EGFR)-mediated tumour growth in the treatment of selected human malignancies, there is a need to determine the expression levels of EGFR and to evaluate its prognostic value in various malignancies in the Asia-Pacific region. Methods and results: A total of 172 patients with head and neck squamous cell carcinomas from Australia, Hong Kong, Singapore, and Taiwan were selected for EGFR detection. Immunohistochemical staining was performed to evaluate EGFR expression. EGFR expression was present in 88.4% (152/172) of all cases tested. Specifically, EGFR expression was found in 91.3% (42/46), 84.6% (22/26), 84.1% (37/44), 96.0% (24/25), and 87.1% (27/31) cases of head and neck squamous cell carcinomas from the oral cavity, oropharynx, nasopharynx, hypopharynx, and larynx, respectively. The results demonstrate a stronger EGFR expression in T4 tumours (P = 0.017) and later clinical stages (P = 0.016). No significant correlation was seen with risk factors, primary tumour site and ethnicity. Conclusions: The majority of head and neck squamous cell carcinomas express EGFR, indicating the importance of studying the efficacy of anti-cancer therapy through this pathway. The results also show similar rates of receptor expression in head and neck squamous cell carcinoma patients from our region compared with other parts of the world.

AB - Aims: With ongoing efforts to target the epidermal growth factor receptor (EGFR)-mediated tumour growth in the treatment of selected human malignancies, there is a need to determine the expression levels of EGFR and to evaluate its prognostic value in various malignancies in the Asia-Pacific region. Methods and results: A total of 172 patients with head and neck squamous cell carcinomas from Australia, Hong Kong, Singapore, and Taiwan were selected for EGFR detection. Immunohistochemical staining was performed to evaluate EGFR expression. EGFR expression was present in 88.4% (152/172) of all cases tested. Specifically, EGFR expression was found in 91.3% (42/46), 84.6% (22/26), 84.1% (37/44), 96.0% (24/25), and 87.1% (27/31) cases of head and neck squamous cell carcinomas from the oral cavity, oropharynx, nasopharynx, hypopharynx, and larynx, respectively. The results demonstrate a stronger EGFR expression in T4 tumours (P = 0.017) and later clinical stages (P = 0.016). No significant correlation was seen with risk factors, primary tumour site and ethnicity. Conclusions: The majority of head and neck squamous cell carcinomas express EGFR, indicating the importance of studying the efficacy of anti-cancer therapy through this pathway. The results also show similar rates of receptor expression in head and neck squamous cell carcinoma patients from our region compared with other parts of the world.

KW - EGFR

KW - Head and neck cancer

KW - Squamous cell carcinoma

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