Expression of cyclooxygenase-2 in prostate adenocarcinoma and benign prostatic hyperplasia

L. M. Lee, C. C. Pan, C. J. Cheng, C. W. Chi, T. Y. Liu

研究成果: 雜誌貢獻文章

85 引文 斯高帕斯(Scopus)

摘要

Elevated expression of cyclo-oxygenase (COX)-2 has been found in several human cancers, including prostate adenocarcinoma. To evaluate the potential prognostic role of COX-2 in prostate cancer, we assessed the expression of COX-2 in benign prostatic hyperplasia (BPH) and prostate cancer samples employing immunohistochemistry. COX-2 was over-expressed in 15 out of 18 (83%) prostate cancer samples whereas it was detected in only 22% (4 of 18) paired benign tissues. The intensity of immunostaining correlated with the tumor grading. In addition, COX-2 was expressed in 7 of the 22 (32%) BPH samples examined. The significance a COX-2 expression in the BPH samples is not known at present. This data suggest that COX-2 is over-expressed in prostate cancer and COX-2 inhibitors may be useful in combination chemotherapy or chemoprevention for prostate cancer.

原文英語
頁(從 - 到)1291-1294
頁數4
期刊Anticancer Research
21
發行號2 B
出版狀態已發佈 - 2001
對外發佈Yes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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