Expression of cyclooxygenase-2 in prostate adenocarcinoma and benign prostatic hyperplasia

L. M. Lee, C. C. Pan, C. J. Cheng, C. W. Chi, T. Y. Liu

研究成果: 雜誌貢獻文章

85 引文 (Scopus)

摘要

Elevated expression of cyclo-oxygenase (COX)-2 has been found in several human cancers, including prostate adenocarcinoma. To evaluate the potential prognostic role of COX-2 in prostate cancer, we assessed the expression of COX-2 in benign prostatic hyperplasia (BPH) and prostate cancer samples employing immunohistochemistry. COX-2 was over-expressed in 15 out of 18 (83%) prostate cancer samples whereas it was detected in only 22% (4 of 18) paired benign tissues. The intensity of immunostaining correlated with the tumor grading. In addition, COX-2 was expressed in 7 of the 22 (32%) BPH samples examined. The significance a COX-2 expression in the BPH samples is not known at present. This data suggest that COX-2 is over-expressed in prostate cancer and COX-2 inhibitors may be useful in combination chemotherapy or chemoprevention for prostate cancer.

原文英語
頁(從 - 到)1291-1294
頁數4
期刊Anticancer Research
21
發行號2 B
出版狀態已發佈 - 2001
對外發佈Yes

指紋

Prostatic Hyperplasia
Cyclooxygenase 2
Prostaglandin-Endoperoxide Synthases
Prostate
Prostatic Neoplasms
Adenocarcinoma
Cyclooxygenase Inhibitors
Neoplasm Grading
Chemoprevention
Combination Drug Therapy
Immunohistochemistry

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

引用此文

Expression of cyclooxygenase-2 in prostate adenocarcinoma and benign prostatic hyperplasia. / Lee, L. M.; Pan, C. C.; Cheng, C. J.; Chi, C. W.; Liu, T. Y.

於: Anticancer Research, 卷 21, 編號 2 B, 2001, p. 1291-1294.

研究成果: 雜誌貢獻文章

Lee, LM, Pan, CC, Cheng, CJ, Chi, CW & Liu, TY 2001, 'Expression of cyclooxygenase-2 in prostate adenocarcinoma and benign prostatic hyperplasia', Anticancer Research, 卷 21, 編號 2 B, 頁 1291-1294.
Lee, L. M. ; Pan, C. C. ; Cheng, C. J. ; Chi, C. W. ; Liu, T. Y. / Expression of cyclooxygenase-2 in prostate adenocarcinoma and benign prostatic hyperplasia. 於: Anticancer Research. 2001 ; 卷 21, 編號 2 B. 頁 1291-1294.
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abstract = "Elevated expression of cyclo-oxygenase (COX)-2 has been found in several human cancers, including prostate adenocarcinoma. To evaluate the potential prognostic role of COX-2 in prostate cancer, we assessed the expression of COX-2 in benign prostatic hyperplasia (BPH) and prostate cancer samples employing immunohistochemistry. COX-2 was over-expressed in 15 out of 18 (83{\%}) prostate cancer samples whereas it was detected in only 22{\%} (4 of 18) paired benign tissues. The intensity of immunostaining correlated with the tumor grading. In addition, COX-2 was expressed in 7 of the 22 (32{\%}) BPH samples examined. The significance a COX-2 expression in the BPH samples is not known at present. This data suggest that COX-2 is over-expressed in prostate cancer and COX-2 inhibitors may be useful in combination chemotherapy or chemoprevention for prostate cancer.",
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AU - Pan, C. C.

AU - Cheng, C. J.

AU - Chi, C. W.

AU - Liu, T. Y.

PY - 2001

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N2 - Elevated expression of cyclo-oxygenase (COX)-2 has been found in several human cancers, including prostate adenocarcinoma. To evaluate the potential prognostic role of COX-2 in prostate cancer, we assessed the expression of COX-2 in benign prostatic hyperplasia (BPH) and prostate cancer samples employing immunohistochemistry. COX-2 was over-expressed in 15 out of 18 (83%) prostate cancer samples whereas it was detected in only 22% (4 of 18) paired benign tissues. The intensity of immunostaining correlated with the tumor grading. In addition, COX-2 was expressed in 7 of the 22 (32%) BPH samples examined. The significance a COX-2 expression in the BPH samples is not known at present. This data suggest that COX-2 is over-expressed in prostate cancer and COX-2 inhibitors may be useful in combination chemotherapy or chemoprevention for prostate cancer.

AB - Elevated expression of cyclo-oxygenase (COX)-2 has been found in several human cancers, including prostate adenocarcinoma. To evaluate the potential prognostic role of COX-2 in prostate cancer, we assessed the expression of COX-2 in benign prostatic hyperplasia (BPH) and prostate cancer samples employing immunohistochemistry. COX-2 was over-expressed in 15 out of 18 (83%) prostate cancer samples whereas it was detected in only 22% (4 of 18) paired benign tissues. The intensity of immunostaining correlated with the tumor grading. In addition, COX-2 was expressed in 7 of the 22 (32%) BPH samples examined. The significance a COX-2 expression in the BPH samples is not known at present. This data suggest that COX-2 is over-expressed in prostate cancer and COX-2 inhibitors may be useful in combination chemotherapy or chemoprevention for prostate cancer.

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