Expression of carbonic anhydrases I/II and the correlation to clinical aspects of oral squamous cell carcinoma analyzed using tissue microarray

Chia Ming Liu, Yueh Min Lin, Kun Tu Yeh, Mu Kuan Chen, Jer Hwa Chang, Chih Jung Chen, Ming Yung Chou, Shun Fa Yang, Ming Hsien Chien

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

摘要

Background: Carbonic anhydrases (CA), a family of metalloenzymes, play an important role in catalyzing the equilibration of carbon dioxide (CO2) and carbonic acid (H2CO3). The role of CAs in tumorigenesis is controversial, especially regarding the expression of CA isoenzymes between various tumor types. This study explores the correlation between the expressions of CA I and CA II and the characteristic features of oral cancer. Methods: We immunohistochemically examined the expressions of CA I and CA II in 279 cases of oral squamous cell carcinoma (OSCC) using tissue microarrays. Additionally, the oral cancer cell line SCC-9 was used to confirm the relationship between CA I and CA II expression and cell growth. Results: We found a significant correlation between positive CA I and CA II stains and OSCC for more advanced clinical stage (P=0.014 or 0.012) and larger tumor size (P=0.008 or 0.038), but not for positive lymph node metastasis, distal metastasis, and recurrence. In vitro analysis also showed that treatment with a CA inhibitor, acetazolamide, inhibited the growth of SCC-9 cells. Conclusion: We conclude that expressions of CA I and CA II in OSCC samples can be used to predict local tumor growth in OSCC patients.
原文英語
頁(從 - 到)533-539
頁數7
期刊Journal of Oral Pathology and Medicine
41
發行號7
DOIs
出版狀態已發佈 - 八月 2012

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oral Surgery
  • Periodontics

指紋 深入研究「Expression of carbonic anhydrases I/II and the correlation to clinical aspects of oral squamous cell carcinoma analyzed using tissue microarray」主題。共同形成了獨特的指紋。

  • 引用此