Exposure to environmental tobacco smoke and urinary 1-hydroxypyrene levels in preschool children

Hsiu Ting Tsai, Ming Tsang Wu, Russ Hauser, Ema Rodrigues, Chi Kung Ho, Chia Ling Liu, David C. Christiani

研究成果: 雜誌貢獻文章

19 引文 (Scopus)

摘要

Environmental tobacco smoke (ETS) contains relatively high concentrations of polycyclic aromatic hydrocarbons (PAHs). Urinary 1-hydroxypyrene (1-OHP), a metabolite of pyrene, is a good indicator of PAH exposure in occupational studies. In this study, we investigated the relationship between urinary 1-OHP concentration and ETS exposure in preschool children. Forty preschool children, aged 24-76 months, were studied during November and December, 1999. Two spot-urine specimens (one in the morning immediately after the subject woke up and the other at night before the subject went to bed) were collected 1 day after completion of a questionnaire, in order to determine 1-OHP concentrations by fluorescent spectrophotometry. Overall, urinary 1-OHP concentrations were relatively low but detectable (morning: median, 0.021 μg/g creatinine; range, 0.002-1.019 μg/g creatinine; night: median, 0.015 μg/g creatinine; range, 0.002-1.328 μg/g creatinine). Multiple linear regression analyses revealed that the total number of cigarettes smoked by the children's fathers during the 3 days prior to collection of the urine specimens was significantly associated with their urinary 1-OHP concentrations, after adjusting for other confounders. Each cigarette smoked by a child's father resulted in an average 9.6% increase in 1-OHP concentration in the morning urine specimen (95% confidence interval = 1.8-18.1%; p = 0.02). We did not find a significant increase in the 1-OHP concentration in night urine specimens (p = 0.19). Although the sample size was small, these findings indicate that urinary 1-OHP may be a suitable biomarker of ETS carcinogen exposure in children.

原文英語
頁(從 - 到)97-104
頁數8
期刊Kaohsiung Journal of Medical Sciences
19
發行號3
出版狀態已發佈 - 三月 1 2003
對外發佈Yes

指紋

Environmental Exposure
Preschool Children
Smoke
Tobacco
Creatinine
Polycyclic Aromatic Hydrocarbons
Urine
Tobacco Products
Fathers
Urine Specimen Collection
Spectrophotometry
Occupational Exposure
Carcinogens
Sample Size
Linear Models
Biomarkers
Regression Analysis
Confidence Intervals
1-hydroxypyrene

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Tsai, H. T., Wu, M. T., Hauser, R., Rodrigues, E., Ho, C. K., Liu, C. L., & Christiani, D. C. (2003). Exposure to environmental tobacco smoke and urinary 1-hydroxypyrene levels in preschool children. Kaohsiung Journal of Medical Sciences, 19(3), 97-104.

Exposure to environmental tobacco smoke and urinary 1-hydroxypyrene levels in preschool children. / Tsai, Hsiu Ting; Wu, Ming Tsang; Hauser, Russ; Rodrigues, Ema; Ho, Chi Kung; Liu, Chia Ling; Christiani, David C.

於: Kaohsiung Journal of Medical Sciences, 卷 19, 編號 3, 01.03.2003, p. 97-104.

研究成果: 雜誌貢獻文章

Tsai, HT, Wu, MT, Hauser, R, Rodrigues, E, Ho, CK, Liu, CL & Christiani, DC 2003, 'Exposure to environmental tobacco smoke and urinary 1-hydroxypyrene levels in preschool children', Kaohsiung Journal of Medical Sciences, 卷 19, 編號 3, 頁 97-104.
Tsai, Hsiu Ting ; Wu, Ming Tsang ; Hauser, Russ ; Rodrigues, Ema ; Ho, Chi Kung ; Liu, Chia Ling ; Christiani, David C. / Exposure to environmental tobacco smoke and urinary 1-hydroxypyrene levels in preschool children. 於: Kaohsiung Journal of Medical Sciences. 2003 ; 卷 19, 編號 3. 頁 97-104.
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