Exploring physical determinants of premetastatic niche with organotypic metastasis-on-a-chip

Chun Wei Lee, Hsueh Yao Chu, Ming Hsuan Chiu, Yin Ju Chen, Long Sheng Lu, Fan Gang Tseng

研究成果: 書貢獻/報告類型會議貢獻

摘要

This research is to develop a novel organotypic metastases-on-a-chip to understand how biophysical factors contribute to the formation of a premetastatic niche. A premetastatic niche refers to the unique microenvironment in destiny organs that receives metastatic cancer cells. Understanding its physical determinants may add to facilitate discovery of potential microenvironment modifiers as new anti-metastasis strategy. we have manufactured and characterized an alginate hydrogel tube (AHT), a manufacturing process based on divalent ion curing will give rise to AHTs with combination of physical properties including submicron surface topography, stiffness, and molecular sieve pore size. The process parameters will be optimized to obtain biomimetic physical properties of the bone marrow microenvironment. Based on studies on tumor microenvironment and our preliminary results.
原文英語
主出版物標題22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
發行者Chemical and Biological Microsystems Society
頁面1579-1581
頁數3
ISBN(電子)9781510897571
出版狀態已發佈 - 一月 1 2018
事件22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, 臺灣
持續時間: 十一月 11 2018十一月 15 2018

出版系列

名字22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
3

會議

會議22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
國家臺灣
城市Kaohsiung
期間11/11/1811/15/18

ASJC Scopus subject areas

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

指紋 深入研究「Exploring physical determinants of premetastatic niche with organotypic metastasis-on-a-chip」主題。共同形成了獨特的指紋。

  • 引用此

    Lee, C. W., Chu, H. Y., Chiu, M. H., Chen, Y. J., Lu, L. S., & Tseng, F. G. (2018). Exploring physical determinants of premetastatic niche with organotypic metastasis-on-a-chip. 於 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 (頁 1579-1581). (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018; 卷 3). Chemical and Biological Microsystems Society.