Exploring mania-associated white matter injury by comparison with multiple sclerosis: a diffusion tensor imaging study

Niccolò Piaggio, Simona Schiavi, Matteo Martino, Giulia Bommarito, Matilde Inglese, Paola Magioncalda

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

Bipolar disorder (BD), especially in its active phases, has shown some neuroimaging and immunological similarities with multiple sclerosis (MS). The objective of this study was to compare white matter (WM) alterations in BD patients in manic phase (M-BD) and MS patients at early stage of disease and with low lesion burden. We compared diffusion tensor imaging (DTI)-derived fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) in a priori selected WM regions (i.e., corpus callosum and cingulum) betwixt 23 M-BD, 23 MS patients and 46 healthy controls. Both M-BD and MS showed WM changes in the corpus callosum, which, however, showed a greater impairment in MS patients. However, considering the different sub-regions of corpus callosum separately (i.e., genu, body, splenium), M-BD and MS presented an opposite pattern in spatial distribution of WM microstructure alterations, with a greater impairment in the anterior region in M-BD and in the posterior region in MS. Common features as well as divergent patterns in DTI changes are detected in M-BD and early MS, prompting a deeper investigation of analogies and differences in WM and immunological alterations of these disorders.

原文英語
頁(從 - 到)78-84
頁數7
期刊Psychiatry Research - Neuroimaging
281
DOIs
出版狀態已發佈 - 十一月 30 2018
對外發佈

ASJC Scopus subject areas

  • 神經科學(雜項)
  • 放射學、核子醫學和影像學
  • 精神病學和心理健康

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