Experimental verification of a two-dimensional respiratory motion compensation system with ultrasound tracking technique in radiation therapy

Lai Lei Ting, Ho Chiao Chuang, Ai Ho Liao, Chia Chun Kuo, Hsiao Wei Yu, Yi Liang Zhou, Der Chi Tien, Shiu Chen Jeng, Jeng Fong Chiou

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

This study proposed respiratory motion compensation system (RMCS) combined with an ultrasound image tracking algorithm (UITA) to compensate for respiration-induced tumor motion during radiotherapy, and to address the problem of inaccurate radiation dose delivery caused by respiratory movement. This study used an ultrasound imaging system to monitor respiratory movements combined with the proposed UITA and RMCS for tracking and compensation of the respiratory motion. Respiratory motion compensation was performed using prerecorded human respiratory motion signals and also sinusoidal signals. A linear accelerator was used to deliver radiation doses to GAFchromic EBT3 dosimetry film, and the conformity index (CI), root-mean-square error, compensation rate (CR), and planning target volume (PTV) were used to evaluate the tracking and compensation performance of the proposed system. Human respiratory pattern signals were captured using the UITA and compensated by the RMCS, which yielded CR values of 34–78%. In addition, the maximum coronal area of the PTV ranged from 85.53 mm2 to 351.11 mm2 (uncompensated), which reduced to from 17.72 mm2 to 66.17 mm2 after compensation, with an area reduction ratio of up to 90%. In real-time monitoring of the respiration compensation state, the CI values for 85% and 90% isodose areas increased to 0.7 and 0.68, respectively. The proposed UITA and RMCS can reduce the movement of the tracked target relative to the LINAC in radiation therapy, thereby reducing the required size of the PTV margin and increasing the effect of the radiation dose received by the treatment target.

原文英語
頁(從 - 到)11-18
頁數8
期刊Physica Medica
49
DOIs
出版狀態已發佈 - 五月 1 2018

指紋

radiation therapy
Radiotherapy
planning
Respiration
respiration
Film Dosimetry
Radiation
dosage
Particle Accelerators
radiation
Radiation Effects
Ultrasonography
root-mean-square errors
linear accelerators
dosimeters
margins
delivery
tumors
Neoplasms

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)

引用此文

Experimental verification of a two-dimensional respiratory motion compensation system with ultrasound tracking technique in radiation therapy. / Ting, Lai Lei; Chuang, Ho Chiao; Liao, Ai Ho; Kuo, Chia Chun; Yu, Hsiao Wei; Zhou, Yi Liang; Tien, Der Chi; Jeng, Shiu Chen; Chiou, Jeng Fong.

於: Physica Medica, 卷 49, 01.05.2018, p. 11-18.

研究成果: 雜誌貢獻文章

Ting, Lai Lei ; Chuang, Ho Chiao ; Liao, Ai Ho ; Kuo, Chia Chun ; Yu, Hsiao Wei ; Zhou, Yi Liang ; Tien, Der Chi ; Jeng, Shiu Chen ; Chiou, Jeng Fong. / Experimental verification of a two-dimensional respiratory motion compensation system with ultrasound tracking technique in radiation therapy. 於: Physica Medica. 2018 ; 卷 49. 頁 11-18.
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abstract = "This study proposed respiratory motion compensation system (RMCS) combined with an ultrasound image tracking algorithm (UITA) to compensate for respiration-induced tumor motion during radiotherapy, and to address the problem of inaccurate radiation dose delivery caused by respiratory movement. This study used an ultrasound imaging system to monitor respiratory movements combined with the proposed UITA and RMCS for tracking and compensation of the respiratory motion. Respiratory motion compensation was performed using prerecorded human respiratory motion signals and also sinusoidal signals. A linear accelerator was used to deliver radiation doses to GAFchromic EBT3 dosimetry film, and the conformity index (CI), root-mean-square error, compensation rate (CR), and planning target volume (PTV) were used to evaluate the tracking and compensation performance of the proposed system. Human respiratory pattern signals were captured using the UITA and compensated by the RMCS, which yielded CR values of 34–78{\%}. In addition, the maximum coronal area of the PTV ranged from 85.53 mm2 to 351.11 mm2 (uncompensated), which reduced to from 17.72 mm2 to 66.17 mm2 after compensation, with an area reduction ratio of up to 90{\%}. In real-time monitoring of the respiration compensation state, the CI values for 85{\%} and 90{\%} isodose areas increased to 0.7 and 0.68, respectively. The proposed UITA and RMCS can reduce the movement of the tracked target relative to the LINAC in radiation therapy, thereby reducing the required size of the PTV margin and increasing the effect of the radiation dose received by the treatment target.",
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AU - Yu, Hsiao Wei

AU - Zhou, Yi Liang

AU - Tien, Der Chi

AU - Jeng, Shiu Chen

AU - Chiou, Jeng Fong

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AB - This study proposed respiratory motion compensation system (RMCS) combined with an ultrasound image tracking algorithm (UITA) to compensate for respiration-induced tumor motion during radiotherapy, and to address the problem of inaccurate radiation dose delivery caused by respiratory movement. This study used an ultrasound imaging system to monitor respiratory movements combined with the proposed UITA and RMCS for tracking and compensation of the respiratory motion. Respiratory motion compensation was performed using prerecorded human respiratory motion signals and also sinusoidal signals. A linear accelerator was used to deliver radiation doses to GAFchromic EBT3 dosimetry film, and the conformity index (CI), root-mean-square error, compensation rate (CR), and planning target volume (PTV) were used to evaluate the tracking and compensation performance of the proposed system. Human respiratory pattern signals were captured using the UITA and compensated by the RMCS, which yielded CR values of 34–78%. In addition, the maximum coronal area of the PTV ranged from 85.53 mm2 to 351.11 mm2 (uncompensated), which reduced to from 17.72 mm2 to 66.17 mm2 after compensation, with an area reduction ratio of up to 90%. In real-time monitoring of the respiration compensation state, the CI values for 85% and 90% isodose areas increased to 0.7 and 0.68, respectively. The proposed UITA and RMCS can reduce the movement of the tracked target relative to the LINAC in radiation therapy, thereby reducing the required size of the PTV margin and increasing the effect of the radiation dose received by the treatment target.

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