Experimental oligohydramnios decreases collagen in hypoplastic fetal rat lungs

Chung Ming Chen, Hsiu Chu Chou, Leng-Fang Wang, Yaw Dong Lang

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

Neonates with premature rupture of the membrane and oligohydramnios have an increased risk of acute respiratory morbidity. The aims of this study are to investigate the effects of experimental oligohydramnios on transforming growth factor (TGF)-β and connective tissue growth factor (CTGF) expressions and collagen level in fetal rat lungs. On day 16 of gestation, we anesthetized timed pregnant Sprague-Dawley dams, punctured the uterine wall and fetal membranes of each amniotic sac which resulted in oligohydramnios. Fetuses in the opposite uterine horn served as controls. On days 19 and 21 of gestation, fetuses were delivered by cesarean section. Rats exposed to oligohydramnios exhibited significantly lower lung weight/body weight ratios on days 19 and 21 of gestation than did the control rats. Lung type I collagen and TGF-β1 mRNA expressions and lung collagen levels were significantly decreased in rats exposed to oligohydramnios on days 19 and 21 of gestation. Type I collagen and inhibitors of metalloproteinase- 1 (TIMP-1) proteins were decreased and matrix metalloprotein- ase-1 (MMP-1) was increased in oligohydramnios-exposed rats on days 19 and 21 of gestation. CTGF mRNA expressions were comparable between control and oligohydramnios-exposed rats on days 19 and 21 of gestation. These data suggest that downregulation of collagen might be involved in the patho- genesis of oligohydramnios-induced respiratory morbidity.
原文英語
頁(從 - 到)1334-1340
頁數7
期刊Experimental Biology and Medicine
233
發行號11
DOIs
出版狀態已發佈 - 十一月 2008

ASJC Scopus subject areas

  • 生物化學、遺傳與分子生物學 (全部)

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