Experience of intravenous immunoglobulin and acyclovir in neonates at risk for severe varicella infection--report of five cases.

S. J. Lin, T. Y. Lin, C. H. Chiu, Y. C. Huang

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

Five cases of at-risk neonates for severe varicella infection were reported. Intravenous immunoglobulin (IVIG) was given soon after birth in different ways to four of them (Case 1 received 400 mg/kg/day for the first three days of life; Case 2 received a single dose of 200 mg/kg on day 2, and another dose of 160 mg/kg on day 7; Cases 3 and 4 received 400 mg/kg on day 2). All five patients were given acyclovir therapy, 40 to 45 mg/kg/day for five to nine days. (Case 1 for prophylaxis, Cases 2, 3, 4, 5 for treatment). Case 2, 3, 4, 5 developed vesicular rash, mild to moderate in degree, with rapid resolution without any constitutional symptoms. Case 1, who received both IVIG and acyclovir for prophylaxis, had no vesicle occurrence. IVIG, in combination with acyclovir, is a safe and probably effective regimen for preventing severe varicella in at-risk neonates. A multi-centered, collaborative study is mandatory to study the efficacy of prophylactic acyclovir with IVIG in these neonates.
原文英語
頁(從 - 到)53-57
頁數5
期刊Acta Paediatrica Sinica
36
發行號1
出版狀態已發佈 - 一月 1995
對外發佈

ASJC Scopus subject areas

  • 兒科、圍產兒和兒童健康

指紋

深入研究「Experience of intravenous immunoglobulin and acyclovir in neonates at risk for severe varicella infection--report of five cases.」主題。共同形成了獨特的指紋。

引用此