Exosomes from the tumor microenvironment as reciprocal regulators that enhance prostate cancer progression

Che Ming Liu, Chia Ling Hsieh, Chia Ning Shen, Cheng Chieh Lin, Katsumi Shigemura, Shian Ying Sung

研究成果: 雜誌貢獻回顧型文獻

17 引文 斯高帕斯(Scopus)

摘要

Distant organ metastasis of prostate cancer is a puzzle, and various theories have successively arisen to explain the mechanism of lethal cancer progression. While perhaps agreeable to many cancer biologists, the very statement of “seed and soil” proposed by Stephan Paget in 1881 is arguably still the major statement for organ-specific cancer metastasis. Since recent studies showed important correlations of regulation of cancer cells and the microenvironment, exosomes from cancer and stromal cells seem to create another important niche for metastasis. Stromal cells pretreated with exosomes from metastatic cancer cells increase the potential of change stromal cells. The poorly metastatic cancer cells could also enhance malignancy through transfer of proteins, microribonucleic acid and messenger ribonucleic acid to recipient cancer cells. Herein, we reviewed extracellular exosomes as a factor involved in cross-talk between stromal and prostate cancer epithelial cells.
原文英語
頁(從 - 到)734-744
頁數11
期刊International Journal of Urology
23
發行號9
DOIs
出版狀態已發佈 - 九月 1 2016

ASJC Scopus subject areas

  • Urology

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