Exogenous reinfection in tuberculosis

Chen Yuan Chiang, Lee W. Riley

研究成果: 雜誌貢獻文章

116 引文 斯高帕斯(Scopus)

摘要

Whether the development of active tuberculosis in people with previous tuberculous infection represents an episode of endogenous reactivation or exogenous reinfection has been debated for decades. Articles proposing the unitary concept of pathogenesis of tuberculosis in the 1960s initiated a period in which reinfection was considered to be an uncommon cause of tuberculosis. To review evidence demonstrating the occurrence of tuberculosis due to exogenous reinfection, we did a literature search covering publications from 1966 until the present, and found that there was substantial evidence - both experimental and epidemiological - supporting the role of exogenous reinfection in tuberculosis. However, only models based on estimates of the annual risk of infection and the incidence of tuberculosis provided a quantitative estimate of the relative contribution of exogenous reinfection to the burden of tuberculosis. Better estimates of the contribution of exogenous reinfection to new cases of tuberculosis may need to be considered in tuberculosis control strategies.

原文英語
頁(從 - 到)629-636
頁數8
期刊Lancet Infectious Diseases
5
發行號10
DOIs
出版狀態已發佈 - 十月 2005
對外發佈Yes

ASJC Scopus subject areas

  • Infectious Diseases

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