Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats

Wei Kung Chen, Ying Lan Tsai, Marthandam Asokan Shibu, Chia Yao Shen, Shu Nu Chang-Lee, Ray Jade Chen, Chun Hsu Yao, Bo Ban, Wei Wen Kuo, Chih Yang Huang

研究成果: 雜誌貢獻文章

12 引文 斯高帕斯(Scopus)

摘要

Exercise is known to be beneficial in controlling aging associated disorders however, the consequence of long-term exercise on cardiac health among aging population is not much clear. In this study the protective effect of exercise on aging associated cardiac disorders was determined using a D-galactose-induced aging model. Eight weeks old Sprague Dawley rats were given intraperitoneal injection of 150 mL/kg D-galactose. Swimming exercise was provided in warm water for 60 min/day for five days per week. Hematoxylin and eosin staining of cardiac tissue sections revealed cardiomyocyte disarrangements in the aging rat hearts but long-term exercise training showed improvements in the cardiac histology. Exercise training also enhanced the expression levels of proteins such as SIRT1, PGC-1α and α1 that are associated with energy homeostasis and further suppressed aging associated inflammatory cytokines. Our results show that longterm exercise training potentially enhances SIRT1 associated anti-aging signaling and provide cardio-protection against aging.
原文英語
頁(從 - 到)4166-4174
頁數9
期刊Aging
10
發行號12
DOIs
出版狀態已發佈 - 十二月 1 2018

ASJC Scopus subject areas

  • Ageing
  • Cell Biology

指紋 深入研究「Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats」主題。共同形成了獨特的指紋。

  • 引用此

    Chen, W. K., Tsai, Y. L., Shibu, M. A., Shen, C. Y., Chang-Lee, S. N., Chen, R. J., Yao, C. H., Ban, B., Kuo, W. W., & Huang, C. Y. (2018). Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats. Aging, 10(12), 4166-4174. https://doi.org/10.18632/aging.101714