Exercise is known to be beneficial in controlling aging associated disorders however, the consequence of long-term exercise on cardiac health among aging population is not much clear. In this study the protective effect of exercise on aging associated cardiac disorders was determined using a D-galactose-induced aging model. Eight weeks old Sprague Dawley rats were given intraperitoneal injection of 150 mL/kg D-galactose. Swimming exercise was provided in warm water for 60 min/day for five days per week. Hematoxylin and eosin staining of cardiac tissue sections revealed cardiomyocyte disarrangements in the aging rat hearts but long-term exercise training showed improvements in the cardiac histology. Exercise training also enhanced the expression levels of proteins such as SIRT1, PGC-1α and α1 that are associated with energy homeostasis and further suppressed aging associated inflammatory cytokines. Our results show that longterm exercise training potentially enhances SIRT1 associated anti-aging signaling and provide cardio-protection against aging.
ASJC Scopus subject areas
- Cell Biology
Chen, W. K., Tsai, Y. L., Shibu, M. A., Shen, C. Y., Chang-Lee, S. N., Chen, R. J., Yao, C. H., Ban, B., Kuo, W. W., & Huang, C. Y. (2018). Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats. Aging, 10(12), 4166-4174. https://doi.org/10.18632/aging.101714