摘要
Exercise is known to be beneficial in controlling aging associated disorders however, the consequence of long-term exercise on cardiac health among aging population is not much clear. In this study the protective effect of exercise on aging associated cardiac disorders was determined using a D-galactose-induced aging model. Eight weeks old Sprague Dawley rats were given intraperitoneal injection of 150 mL/kg D-galactose. Swimming exercise was provided in warm water for 60 min/day for five days per week. Hematoxylin and eosin staining of cardiac tissue sections revealed cardiomyocyte disarrangements in the aging rat hearts but long-term exercise training showed improvements in the cardiac histology. Exercise training also enhanced the expression levels of proteins such as SIRT1, PGC-1α and α1 that are associated with energy homeostasis and further suppressed aging associated inflammatory cytokines. Our results show that longterm exercise training potentially enhances SIRT1 associated anti-aging signaling and provide cardio-protection against aging.
原文 | 英語 |
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頁(從 - 到) | 4166-4174 |
頁數 | 9 |
期刊 | Aging |
卷 | 10 |
發行號 | 12 |
DOIs | |
出版狀態 | 已發佈 - 12月 1 2018 |
ASJC Scopus subject areas
- 老化
- 細胞生物學