Exercise renovates H2S and Nrf2-related antioxidant pathways to suppress apoptosis in the natural ageing process of male rat cortex

Jing Ying Lin, Tsung Jung Ho, Bruce Chi Kang Tsai, Chien Yi Chiang, Hui Chuan Kao, Wei Wen Kuo, Ray Jade Chen, Vijaya Padma Viswanadha, Chi Wen Huang, Chih Yang Huang

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

Ageing is a complex biological process that increases the probability of disease and death, which affects the organs of all species. The accumulation of oxidative damage in the brain contributes to a progressive loss of cognitive functions or even declined the energy metabolism. In this study, we tested the effects of exercise training on the apoptosis, survival, and antioxidant signaling pathways in the cerebral cortex of three age groups of male rats; 3, 12, and 18 months. We observed that H2S and the expression of Nrf2-related antioxidant pathways declined with age and increased after exercise training. IGF1R survival pathway was less increased in middle-aged rats; however, significantly increased after exercise training. The expression of mitochondrial-dependent apoptotic pathway components, such as Bak, cytochrome C, and caspase 3 in the ageing control group, were much higher than those of the exercise training groups. This study demonstrated that exercise training could reduce the apoptosis and oxidative stress that accrues throughout ageing, which causes brain damage. Graphic abstract: [Figure not available: see fulltext.].

原文英語
頁(從 - 到)495-506
頁數12
期刊Biogerontology
22
發行號5
DOIs
出版狀態已發佈 - 10月 2021

ASJC Scopus subject areas

  • 老化
  • 老年學
  • 老年病學和老年學

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