Exercise alleviates osteoporosis in rats with mild chronic kidney disease by decreasing sclerostin production

Hung Wei Liao, Tsang Hai Huang, Yi Han Chang, Hung Hsiang Liou, Yu Hsien Chou, Yuh Mou Sue, Peir Haur Hung, Yu Tzu Chang, Pei Chuan Ho, Kuen Jer Tsai

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)

摘要

Chronic kidney disease–mineral bone disorder (CKD–MBD), comprising mineral, hormonal, and bone metabolic imbalance, is a major CKD-related issue; it causes osteoporosis prevalence in CKD patients. Osteocyte-derived sclerostin inhibits the osteogenic Wnt/β-catenin signaling pathway; its levels rise when kidney function declines. Exercise modulates the physiological functions of osteocytes, potentially altering sclerostin production. It may aid bone and mineral electrolyte homeostasis in CKD. Mild CKD was induced in rats by partial nephrectomy. They were divided into: sham (no CKD), CKD, and CKD + exercise (8 weeks of treadmill running) groups. Micro-CT scanning demonstrated that the CKD + exercise-group rats had a higher bone mineral density (BMD) of the spine and femoral metaphysis and higher femoral trabecular bone volume than the CKD-group rats. Bone formation rates were not significantly different. The CKD + exercise-group rats had lower serum sclerostin (157.1 ± 21.1 vs 309 ± 38.1 pg/mL, p < 0.05) and CTX-1 (bone resorption marker) levels. Immunohistochemistry revealed higher tibial β-catenin concentrations in the CKD + exercise-group rats. Serum FGF-23, intact parathyroid hormone (iPTH), alkaline phosphatase (ALP), calcium, and phosphate levels showed no significant differences between these groups. Thus, exercise improves BMD and bone microstructure in mild CKD by inhibiting sclerostin production, but does not alter serum minerals.

原文英語
文章編號2044
期刊International Journal of Molecular Sciences
20
發行號8
DOIs
出版狀態已發佈 - 四月 2 2019

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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    Liao, H. W., Huang, T. H., Chang, Y. H., Liou, H. H., Chou, Y. H., Sue, Y. M., Hung, P. H., Chang, Y. T., Ho, P. C., & Tsai, K. J. (2019). Exercise alleviates osteoporosis in rats with mild chronic kidney disease by decreasing sclerostin production. International Journal of Molecular Sciences, 20(8), [2044]. https://doi.org/10.3390/ijms20082044